Interleukin-13 Promoter Genotypes and Taiwanese Breast Cancer Susceptibility
| Autor: | Chao Hsuan Chen, Jaw-Chyun Chen, Wen-Shin Chang, Chun-Ming Yen, Da Tian Bau, Liang Chih Liu, Hsu-Tung Lee, Chen Hsien Su, Chia-Wen Tsai, Yun-Chi Wang, Hwei Chung Wang, Chung-Lin Tsai |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Taiwan Breast Neoplasms Biology Polymorphism Single Nucleotide Breast cancer Asian People Gene Frequency Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Promoter Regions Genetic Interleukin-13 General Medicine Middle Aged medicine.disease Case-Control Studies Interleukin 13 Female |
| Zdroj: | Anticancer research. 40(12) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim The current study aimed at evaluating the contribution of IL-13 promoter rs1881457 and rs1800925 genotypes to the risk of breast cancer in Taiwan. Materials and methods A total of 1,232 breast cancer cases and 1,232 age-matched controls were genotyped by typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results As for IL-13 rs1881457, the rates of AA, AC and CC genotypes were 54.8, 37.9 and 7.3% among the cases, and 53.8, 38.7 and 7.5% among the healthy controls, respectively; there were no statistically significant differences between the two groups (p for trend=0.8889). Also, regarding IL-13 rs1800925, there were no statistically significant differences between the two groups either (p for trend=0.6803). Furthermore, the allelic frequencies for IL-13 rs1881457 and rs1800925 were not differentially distributed between the case and control groups (p=0.6515 and 0.8753, respectively). Conclusion The rs1881457 and rs1800925 IL-13 promoter polymorphisms may not serve as breast cancer susceptibility determinants for Taiwanese. |
| Databáze: | OpenAIRE |
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