Synthesis and anaerobic activity of novel 1-carba-1-dethiacephalosporins
| Autor: | Jeffrey S. Kasher, Robert J. Ternansky, C. L. Jordan, J. A. Eudaly |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Bicyclic molecule Substituent Biological activity Combinatorial chemistry Cephalosporins Rats Rats Sprague-Dawley Bacteria Anaerobic chemistry.chemical_compound chemistry Drug Discovery Nucleophilic substitution Lactam Animals Molecular Medicine Anaerobic exercise Lead compound Antibacterial agent |
| Zdroj: | Journal of Medicinal Chemistry. 36:2332-2334 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00068a009 |
| Popis: | The synthesis and biological evaluation of novel 1-carba-1-dethiacephalosporins exhibiting activity against anaerobic pathogens are described. The nitrothiazole substituent was determined to be crucial to maintaining this activity. The pharmacokinetic parameters and initial toxicological profile of the lead compound are discussed. |
| Databáze: | OpenAIRE |
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