Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats
| Autor: | Lin Chunbo, Jing Ji, Li Xiaofeng, Xie Furong, Wei-Guo Liang, Yang Yuan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Simvastatin
medicine.medical_specialty Bone density Ovariectomy medicine.medical_treatment Osteocalcin 030209 endocrinology & metabolism Bone remodeling Random Allocation 03 medical and health sciences 0302 clinical medicine Bone Density Internal medicine Quinestrol polycyclic compounds Animals Medicine Pharmacology (medical) 030212 general & internal medicine Rats Wistar Saline Pharmacology Bone mineral biology business.industry General Medicine Alkaline Phosphatase Rats Hydroxyproline Endocrinology Creatinine Ovariectomized rat biology.protein Alkaline phosphatase Calcium Drug Therapy Combination Female business medicine.drug |
| Zdroj: | American Journal of Therapeutics. 23:e1630-e1636 |
| ISSN: | 1075-2765 |
| DOI: | 10.1097/mjt.0000000000000271 |
| Popis: | We aim to compare the effects of simvastatin and combination of simvastatin and nylestriol on bone metabolism in ovariectomized (OVX) rats. Fifty healthy Wistar female rats were randomly allocated into 5 groups: sham + saline group (group A), OVX + saline group (group B), OVX + simvastatin (5 mg·kg·d) (group C), OVX + nylestriol (0.01 mg·kg·d) (group D), and OVX + simvastatin (3 mg·kg·d) + nylestriol (0.005 mg·kg·d) (group E). All mice were orally administrated with saline or medicine dissolved in saline for 10 weeks. Body weight of rats before and after the experiment was measured. Twenty-four hours after the experiment, calcium (Ca), creatinine (Cr), and hydroxyproline in urine were detected. Serum levels of osteocalcin (bone Gla-protein, BGP) and alkaline phosphatase (ALP) were measured. Bone mineral density was detected and trabecular bone was observed after the isolation of femur and tibia. Remarkably decreased serum BGP and increased serum ALP levels were detected in group B compared with those in group A. However, notably increased serum BGP and decreased serum ALP levels were found in groups C, D, and E compared with those in group B; femoral and tibial bone mineral density decreased in group B compared with that in group A, but increased in groups C, D, and E compared with that in group B. Simvastatin and combination of simvastatin and nylestriol promote formation of new bone, increase bone density, and improve bone microstructure damage in OVX rats. |
| Databáze: | OpenAIRE |
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