Treatment of superficial vascular anomalies with topical sirolimus: A multicenter case series
| Autor: | Melissa Dodds, Marcia Hogeling, Leslie Castelo-Soccio, Megha M. Tollefson, Sheilagh Maguiness, Maria C. Garzon, Christina Boull, Kristen P. Hook |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Vascular Malformations Administration Topical Dermatology Vascular anomaly Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine 030225 pediatrics medicine Humans Lymphatic malformations Child Retrospective Studies Sirolimus Lymphatic Abnormalities business.industry Vascular malformation Infant medicine.disease Treatment Outcome Lymphatic system Tolerability Child Preschool Pediatrics Perinatology and Child Health Female Topical Sirolimus Venous malformation business Immunosuppressive Agents medicine.drug |
| Zdroj: | Pediatric Dermatology. 37:272-277 |
| ISSN: | 1525-1470 0736-8046 |
| Popis: | Background Systemic sirolimus (rapamycin) has recently been found effective in treating complex vascular anomalies by reducing the size and associated complications. Many vascular anomalies have a cutaneous component, and thus, we sought to determine whether topical administration of sirolimus may be an effective therapy, as data on the use of topical sirolimus are limited. Objective We reviewed the efficacy and tolerability of topical formulations of sirolimus in the treatment of various simple and combined vascular malformations and tumors. Methods Eighteen patients with any vascular anomaly treated exclusively with topical sirolimus were retrospectively reviewed. Results Eleven patients had combined venous lymphatic malformations, three had tufted angiomas, two had a lymphatic malformation, one had a venous malformation, and one had a verrucous venous malformation. All (100%) patients reported some degree of improvement and 50% of patients reported marked improvement in one or more symptoms, most commonly blebs and lymphatic drainage, and bleeding. Limitations The retrospective nature, small number of patients, and differences in topical preparations limit the broad application of the results. Conclusion Topical sirolimus appears to be a safe and useful non-invasive therapy that is well-tolerated in the treatment of the cutaneous portion of a variety of vascular anomalies. |
| Databáze: | OpenAIRE |
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