Pentoxifylline acutely reduces protein catabolism in chronically uremic patients

Autor: Alessandra Bosutti, Roberta Situlin, Gianni Biolo, Gianfranco Guarnieri, Beniamino Ciocchi, Gabriele Toigo
Přispěvatelé: Biolo, Gianni, Ciocchi, Beniamino, Bosutti, Alessandra, Situlin, Roberta, Toigo, Gabriele, Guarnieri, Gianfranco
Rok vydání: 2002
Předmět:
Zdroj: American Journal of Kidney Diseases. 40:1162-1172
ISSN: 0272-6386
DOI: 10.1053/ajkd.2002.36864
Popis: We investigated the ability of pentoxifylline, a drug with hemorheological actions known to block tumor necrosis factor-alpha (TNF-alpha) release, to modulate whole-body protein kinetics in undialyzed patients with chronic uremia.Leucine rate of appearance (Ra) from proteolysis and leucine oxidation, a marker of net protein loss, were determined by infusing l-[1-13C]leucine and using the reciprocal pool model for calculations.Intravenous infusion of pentoxifylline in the postabsorptive state (1 mg/kg within 3 hours) decreased the intracellular leucine Ra from proteolysis by -16% +/- 4% versus -3% +/- 2% of saline (P = 0.02) and leucine oxidation by -16% +/- 4% versus +4% +/- 2% of saline (P = 0.003). Combined infusions of pentoxifylline and a balanced amino acid mixture (0.2 mg/kg/min) decreased whole-body proteolysis by -53% +/- 7% versus -26% +/- 6% of amino acid infusion alone (P = 0.02). Circulating levels of TNF-alpha and TNF-alpha soluble receptors (sTNF-Rs) were elevated (P0.001) in patients compared with healthy controls. Pentoxifylline infusion did not significantly affect TNF-alpha levels, but decreased sTNF-Rs both in the postabsorptive state and during hyperaminoacidemia.Pentoxifylline acutely decreased whole-body proteolysis in chronically uremic patients. Potential explanations for these pharmacological effects may include downregulation of the TNF-alpha system or other mechanisms related to the rheological action of the drug (eg, increased amino acid or insulin delivery to target cells).
Databáze: OpenAIRE
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