Henoch–Schönlein Purpura Associated with Lung Cancer: When Paraneoplastic Manifestations Impede Oncological Management
| Autor: | Juliette Menguy, Gilles Quéré, Eloïse Philippe, Gilles Robinet, Renaud Descourt, Aude Barnier, Francis Couturaud |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Kidney
medicine.medical_specialty Henoch-Schonlein purpura medicine.diagnostic_test business.industry medicine.medical_treatment Immunology Glomerulonephritis Case Report Immunotherapy RC581-607 medicine.disease Gastroenterology Purpura medicine.anatomical_structure Internal medicine Biopsy medicine Immunology and Allergy medicine.symptom Immunologic diseases. Allergy Lung cancer business Prospective cohort study |
| Zdroj: | Case Reports in Immunology Case Reports in Immunology, Vol 2021 (2021) |
| ISSN: | 2090-6617 2090-6609 |
| Popis: | Background. Henoch–Schönlein purpura (HSP) is an uncommon syndrome that mostly occurs in children, in whom it is frequently triggered by infections. In contrast, HSP in adults is more frequently of neoplastic origin. Case Presentation. We report HSP associated with a locally advanced lung squamous cell carcinoma that was considered a paraneoplastic syndrome. Systemic corticosteroids were given because a kidney biopsy revealed active glomerulonephritis. Concomitant chemoradiotherapy achieved a partial response of the lung tumor. Consolidation immunotherapy (programmed death protein-1-ligand-1 (PD-L1) inhibitor) was cancelled because HSP is known to be an autoimmune vasculitis, and long-term corticosteroid therapy was pursued. Conclusion. Further prospective studies are needed to evaluate the effect of anti-PD-(L) 1 immunotherapies on autoimmune manifestations. |
| Databáze: | OpenAIRE |
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