3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase

Autor:	Fell Jay Bradford, John A. Josey, Steven Swallow, Sophie LePogam, Sonal Rajyaguru, Robert Than Hendricks, James F. Blake, John P. Fischer, Stacey Renee Spencer, Vincent Leveque, Isabel Najera, Stengel Peter J
Rok vydání:	2008
Předmět:	Models Molecular Cellular activity Clinical Biochemistry Pharmaceutical Science RNA-dependent RNA polymerase Viral Nonstructural Proteins Biochemistry chemistry.chemical_compound Structure-Activity Relationship Drug Discovery Structure–activity relationship Replicon Isoquinoline Enzyme Inhibitors Molecular Biology NS5B Polymerase chemistry.chemical_classification biology Chemistry Organic Chemistry virus diseases Isoquinolines RNA-Dependent RNA Polymerase Virology digestive system diseases Enzyme biology.protein Molecular Medicine
Zdroj:	Bioorganicmedicinal chemistry letters. 19(2)
ISSN:	1464-3405
Popis:	Isoquinoline-based non-nucleoside inhibitors of HCV NS5b RNA-dependent RNA-polymerase are described. The synthesis and structure-activity relationships are detailed, along with enzyme and cellular activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6cd9770592c3ebb016fd7919674206 https://pubmed.ncbi.nlm.nih.gov/19070486 Zobrazit plný text záznamu Full Text from ScienceDirect