Primary intestinal-type adenocarcinoma of the oral tongue: Case report and review of histologic origin and oncologic management
| Autor: | Andrew Coughlin, Jenna Berg, Yungpo Bernard Su, Rodolfo E. Manosalva, John Gentry, Tien-Shew Huang |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Adenocarcinoma Malignancy Gastroenterology 03 medical and health sciences 0302 clinical medicine Tongue FOLFOX Internal medicine Metaplasia Adjuvant therapy Humans Medicine business.industry Chemoradiotherapy Adjuvant 030206 dentistry medicine.disease digestive system diseases Tongue Neoplasms medicine.anatomical_structure Otorhinolaryngology Lymphatic Metastasis 030220 oncology & carcinogenesis Glossectomy medicine.symptom business Odynophagia medicine.drug |
| Zdroj: | Head & Neck. 40:E68-E72 |
| ISSN: | 1043-3074 |
| Popis: | Background Primary intestinal-type adenocarcinoma (ITAC) of the oral tongue is an extremely uncommon malignancy with only 3 cases reported in the literature. This high-grade malignancy originates from metaplasia of minor salivary glands. Methods A 40-year-old man presented with a gradually enlarging midline oral tongue mass, odynophagia, and dysphagia. Management included a median lingual glossectomy, bilateral neck dissections, and adjuvant chemoradiation with 5-fluorouracil (5-FU). Additional chemotherapy with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) was given to mimic therapy in colonic adenocarcinomas. Results Thirteen months after surgery and adjuvant chemoradiotherapy, there is no evidence of locoregional or distant disease. His diet and speech have normalized after reconstruction without free tissue transfer. Conclusion We report the fourth case of oral tongue ITAC, and present the first histologic evidence of metaplasia of oral cavity salivary epithelium. We also discuss adjuvant therapy recommendations given the lack of clarity for treatment of this rare disease. |
| Databáze: | OpenAIRE |
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