Associations of Maternal Leptin with Neonatal Adiposity Differ according to Pregravid Weight
| Autor: | Julie Moreau, Julie Ménard, Guillaume Lacerte, Laetitia Guillemette, Catherine Allard, Myriam Doyon, Marie-France Hivert, Jean-Luc Ardilouze, Marie-Claude Battista, Patrice Perron, Julie Patenaude, Marilyn Lacroix |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Adipose tissue Mothers 030209 endocrinology & metabolism Gestational Age Body Mass Index Fetal Development 03 medical and health sciences Young Adult 0302 clinical medicine Pregnancy Internal medicine Placenta medicine Birth Weight Humans 030212 general & internal medicine Prospective Studies Fetal programming Prospective cohort study Adiposity Fetus business.industry digestive oral and skin physiology Infant Newborn Quebec Glucose Tolerance Test medicine.disease Fetal Blood Endocrinology medicine.anatomical_structure embryonic structures Pediatrics Perinatology and Child Health Linear Models Female business hormones hormone substitutes and hormone antagonists Biomarkers Developmental Biology |
| Zdroj: | Neonatology. 111(4) |
| ISSN: | 1661-7819 |
| Popis: | Background: During pregnancy, maternal circulating leptin is released by maternal adipose tissue and the placenta, and may have a role in fetal development. Objectives: We investigated maternal leptinemia and glycemia associations with neonatal adiposity, taking into account pregravid weight status. Methods: We included 235 pregnant women from the Genetics of Glucose Regulation in Gestation and Growth prospective cohort with data: blood samples collected during the 2nd trimester, an oral glucose tolerance test (OGTT), and the measured leptin and glucose levels. As an integrated measure of maternal leptin exposure, we calculated the area under the curve for maternal leptin at the OGTT (AUCleptin). Within 72 h of delivery, we measured the triceps, biceps, subscapular, and suprailiac skinfold thicknesses (SFTs); the sum of these SFTs represented neonatal adiposity. We conducted a regression analysis to assess the maternal metabolic determinants of neonatal adiposity, adjusting for parity, smoking status, maternal triglyceride levels, gestational weight gain, placental weight, delivery mode, neonate sex, and gestational age at delivery. Results: The pregravid BMI of the participating women was 23.3 (21.2-27.0). In the 2nd trimester, maternal AUCleptin was 1,292.0 (767.0-2,222.5) (ng × min)/mL, and fasting glucose levels were 4.2 ± 0.4 mmol/L. At delivery, the neonatal sum of 4 SFTs was 17.9 ± 3.3 mm. Higher maternal leptinemia was associated with higher neonatal adiposity (β = 4.23 mm [SE = 1.77] per log-AUCleptin; p = 0.02) in mothers with a BMI ≥25, independently of confounders and maternal glycemia, but not in mothers with a BMI p = 0.005) in mothers with a BMI Conclusion: Maternal leptinemia may be associated with neonatal adiposity in offspring from overweight/obese mothers, independently of maternal glycemia. |
| Databáze: | OpenAIRE |
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