Abdominal aortic calcification is associated with a higher risk of injurious fall-related hospitalizations in older Australian women
| Autor: | Kun Zhu, Douglas P. Kiel, Richard L. Prince, Jonathan M. Hodgson, John T. Schousboe, Marc Sim, Pawel Szulc, Catherine P. Bondonno, Abadi Kahsu Gebre, Nicola P. Bondonno, Lauren C. Blekkenhorst, Alexander J. Rodríguez, Joshua R. Lewis |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030204 cardiovascular system & hematology Article 03 medical and health sciences Grip strength 0302 clinical medicine Unit increase Risk Factors Internal medicine medicine Humans Aorta Abdominal Prospective Studies Risk factor Prospective cohort study Vascular Calcification Vascular calcification Aged business.industry Australia Mean age Osteoporosis screening Hospitalization 030104 developmental biology Abdominal aortic calcification Accidental Falls Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis |
| Popis: | Backgrounds and aims Abdominal aortic calcification (AAC) is associated with weaker grip strength, an established risk factor for fall-related hospitalizations. However, its association with long-term fall-related hospitalisations remains unknown. This study investigated the association between AAC and long-term fall-related hospitalizations in community-dwelling older women. Methods Fall-related hospitalizations were obtained from linked data over 14.5-years in a prospective cohort of 1053 older women (mean age 75.0 ± 2.6 years). At baseline (1998/99), AAC was assessed from lateral spine images obtained using dual-energy X-ray absorptiometry, and scored using a semi-quantitative method (AAC24, range 0–24). The presence of any AAC was defined by AAC24 ≥ 1. Results Over 14.5-years, 413 (39.2%) women experienced a fall-related hospitalization. In the multivariable-adjusted model, each unit increase in baseline AAC24 was associated with a 3% increase in relative hazards for a fall-related hospitalization (HR 1.03 95%CI, 1.01 to 1.07). Compared to women with no AAC, women with any AAC had a 40% (HR 1.40 95%CI, 1.11 to 1.76) and 39% (HR 1.39 95%CI, 1.10 to 1.76) greater risk for fall-related hospitalizations in the minimal and multivariable-adjusted models, respectively. This relationship was not attenuated by including measures of muscle function such as grip strength and timed-up-and-go. Conclusions The presence of AAC is associated with long-term fall-related hospitalizations risk, independent of muscle function, in community-dwelling older women. Concurrent assessment of AAC may be a simple and cost-effective way to identify older women at higher risk of falling as part of routine osteoporosis screening. |
| Databáze: | OpenAIRE |
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