The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial
Autor: | Clara Woolhead, John C. Mathers, Rodrigo San-Cristobal, Julie A. Lovegrove, Eileen R. Gibney, Lorraine Brennan, Iwona Traczyk, Hannah Forster, J. Alfredo Martínez, Michael J. Gibney, Marianne C. Walsh, Cyril F. M. Marsaux, Anna L. Macready, Agnieszka Surwiłło, Hannelore Daniel, George Moschonis, Jildau Bouwman, Santiago Navas-Carretero, Christian A. Drevon, Carlos Celis-Morales, Silvia Kolossa, Katherine M. Livingstone, Rosalind Fallaize, Christina Mavrogianni, Jacqueline Hallmann, Wim H. M. Saris, Clare B. O’Donovan, Keith A. Grimaldi, Yannis Manios |
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Přispěvatelé: | Promovendi NTM, Humane Biologie, RS: NUTRIM - HB/BW section A, RS: NUTRIM - R1 - Metabolic Syndrome |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Apolipoprotein E Male Pathology Apolipoprotein E4 Biomedical Innovation Medicine (miscellaneous) Gastroenterology Electronic mail law.invention Cohort Studies chemistry.chemical_compound Nutrigenomics Life Randomized controlled trial law Medicine Precision Medicine personalized nutrition Diet Fat-Restricted Food4me 2. Zero hunger Nutrition and Dietetics Electronic Mail Personalized nutrition 3. Good health Europe Cholesterol Cardiovascular Diseases dietary fat Saturated fatty acid Female Healthy Living APOE Cohort study Food4Me Adult medicine.medical_specialty Patient Dropouts Hypercholesterolemia Polymorphism Single Nucleotide 03 medical and health sciences Patient Education as Topic Internal medicine Fatty Acids Omega-3 Humans Genetic Predisposition to Disease Postal Service Allele Biology Alleles Internet 030109 nutrition & dietetics business.industry MSB - Microbiology and Systems Biology chemistry Patient Compliance ELSS - Earth Life and Social Sciences business Dietary fat |
Zdroj: | American Journal of Clinical Nutrition, 104(3), 827-836. Oxford University Press American Journal of Clinical Nutrition, 3, 104, 827-836 |
ISSN: | 1938-3207 0002-9165 |
Popis: | Background: The apolipoprotein E (APOE) risk allele (e4) is associated with higher total cholesterol (TC), amplified response to saturated fatty acid (SFA) reduction, and increased cardiovascular disease. Although knowledge of gene risk may enhance dietary change, it is unclear whether e4 carriers would benefit from gene-based personalized nutrition (PN). Objectives: The aims of this study were to 1) investigate interactions between APOE genotype and habitual dietary fat intake and modulations of fat intake on metabolic outcomes; 2) determine whether gene-based PN results in greater dietary change than do standard dietary advice (level 0) and nongene-based PN (levels 1-2); and 3) assess the impact of knowledge of APOE risk (risk: E4+, nonrisk: E42) on dietary change after gene-based PN (level 3). Design: Individuals (n = 1466) recruited into the Food4Me pan- European PN dietary intervention study were randomly assigned to 4 treatment arms and genotyped for APOE (rs429358 and rs7412). Diet and dried blood spot TC and v-3 (n-3) index were determined at baseline and after a 6-mo intervention. Data were analyzed with the use of adjusted general linear models. Results: Significantly higher TC concentrations were observed in E4+ participants than in E42 (P , 0.05). Although there were no significant differences in APOE response to gene-based PN (E4+ compared with E42), both groups had a greater reduction in SFA (percentage of total energy) intake than at level 0 (mean 6 SD: E4+, 20.72% 6 0.35% compared with 21.95% 6 0.45%, P = 0.035; E42, 20.31% 6 0.20% compared with 21.68% 6 0.35%, P = 0.029). Gene-based PN was associated with a smaller reduction in SFA intake than in nongene-based PN (level 2) for E42 participants (21.68% 6 0.35% compared with 22.56% 6 0.27%, P = 0.025). Conclusions: The APOE e4 allele was associated with higher TC. Although gene-based PN targeted to APOE was more effective in reducing SFA intake than standard dietary advice, there was no difference between APOE "risk" and "nonrisk" groups. Furthermore, disclosure of APOE nonrisk may have weakened dietary response to PN. This trial was registered at clinicaltrials.gov as NCT01530139. Am J Clin Nutr 2016;104:827-36. © 2016 American Society for Nutrition. |
Databáze: | OpenAIRE |
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