The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: findings from the Food4Me randomized controlled trial

Autor: Clara Woolhead, John C. Mathers, Rodrigo San-Cristobal, Julie A. Lovegrove, Eileen R. Gibney, Lorraine Brennan, Iwona Traczyk, Hannah Forster, J. Alfredo Martínez, Michael J. Gibney, Marianne C. Walsh, Cyril F. M. Marsaux, Anna L. Macready, Agnieszka Surwiłło, Hannelore Daniel, George Moschonis, Jildau Bouwman, Santiago Navas-Carretero, Christian A. Drevon, Carlos Celis-Morales, Silvia Kolossa, Katherine M. Livingstone, Rosalind Fallaize, Christina Mavrogianni, Jacqueline Hallmann, Wim H. M. Saris, Clare B. O’Donovan, Keith A. Grimaldi, Yannis Manios
Přispěvatelé: Promovendi NTM, Humane Biologie, RS: NUTRIM - HB/BW section A, RS: NUTRIM - R1 - Metabolic Syndrome
Rok vydání: 2016
Předmět:
0301 basic medicine
Apolipoprotein E
Male
Pathology
Apolipoprotein E4
Biomedical Innovation
Medicine (miscellaneous)
Gastroenterology
Electronic mail
law.invention
Cohort Studies
chemistry.chemical_compound
Nutrigenomics
Life
Randomized controlled trial
law
Medicine
Precision Medicine
personalized nutrition
Diet
Fat-Restricted
Food4me
2. Zero hunger
Nutrition and Dietetics
Electronic Mail
Personalized nutrition
3. Good health
Europe
Cholesterol
Cardiovascular Diseases
dietary fat
Saturated fatty acid
Female
Healthy Living
APOE
Cohort study
Food4Me
Adult
medicine.medical_specialty
Patient Dropouts
Hypercholesterolemia
Polymorphism
Single Nucleotide
03 medical and health sciences
Patient Education as Topic
Internal medicine
Fatty Acids
Omega-3
Humans
Genetic Predisposition to Disease
Postal Service
Allele
Biology
Alleles
Internet
030109 nutrition & dietetics
business.industry
MSB - Microbiology and Systems Biology
chemistry
Patient Compliance
ELSS - Earth
Life and Social Sciences
business
Dietary fat
Zdroj: American Journal of Clinical Nutrition, 104(3), 827-836. Oxford University Press
American Journal of Clinical Nutrition, 3, 104, 827-836
ISSN: 1938-3207
0002-9165
Popis: Background: The apolipoprotein E (APOE) risk allele (e4) is associated with higher total cholesterol (TC), amplified response to saturated fatty acid (SFA) reduction, and increased cardiovascular disease. Although knowledge of gene risk may enhance dietary change, it is unclear whether e4 carriers would benefit from gene-based personalized nutrition (PN). Objectives: The aims of this study were to 1) investigate interactions between APOE genotype and habitual dietary fat intake and modulations of fat intake on metabolic outcomes; 2) determine whether gene-based PN results in greater dietary change than do standard dietary advice (level 0) and nongene-based PN (levels 1-2); and 3) assess the impact of knowledge of APOE risk (risk: E4+, nonrisk: E42) on dietary change after gene-based PN (level 3). Design: Individuals (n = 1466) recruited into the Food4Me pan- European PN dietary intervention study were randomly assigned to 4 treatment arms and genotyped for APOE (rs429358 and rs7412). Diet and dried blood spot TC and v-3 (n-3) index were determined at baseline and after a 6-mo intervention. Data were analyzed with the use of adjusted general linear models. Results: Significantly higher TC concentrations were observed in E4+ participants than in E42 (P , 0.05). Although there were no significant differences in APOE response to gene-based PN (E4+ compared with E42), both groups had a greater reduction in SFA (percentage of total energy) intake than at level 0 (mean 6 SD: E4+, 20.72% 6 0.35% compared with 21.95% 6 0.45%, P = 0.035; E42, 20.31% 6 0.20% compared with 21.68% 6 0.35%, P = 0.029). Gene-based PN was associated with a smaller reduction in SFA intake than in nongene-based PN (level 2) for E42 participants (21.68% 6 0.35% compared with 22.56% 6 0.27%, P = 0.025). Conclusions: The APOE e4 allele was associated with higher TC. Although gene-based PN targeted to APOE was more effective in reducing SFA intake than standard dietary advice, there was no difference between APOE "risk" and "nonrisk" groups. Furthermore, disclosure of APOE nonrisk may have weakened dietary response to PN. This trial was registered at clinicaltrials.gov as NCT01530139. Am J Clin Nutr 2016;104:827-36. © 2016 American Society for Nutrition.
Databáze: OpenAIRE
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