Preoperative D-dimers as an independent prognostic marker in cervical carcinoma
| Autor: | Hao Chen, Xin Zheng, Lin Zhang, Peidong Chi, Xueping Wang, Yao-Ling Luo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Uterine Cervical Neoplasms Kaplan-Meier Estimate Thrombin time Fibrinogen Gastroenterology Fibrin Fibrinogen Degradation Products Internal medicine D-dimer Fibrinolysis Preoperative Care medicine Biomarkers Tumor Humans Stage (cooking) Blood Coagulation Cervical cancer Prothrombin time medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Prognosis Surgery Prothrombin Time Female business Partial thromboplastin time medicine.drug |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 36(11) |
| ISSN: | 1423-0380 |
| Popis: | Activation of coagulation and fibrinolysis has been observed in many tumors. Our study aimed to investigate the clinical and prognostic significance of various plasma coagulation tests in patients with cervical cancer. A total of 296 patients with cervical cancer were included in the analysis. Patients were followed up for at least 60 months until death. Pretreatment parameters including activated partial thromboplastin time, D-dimer, fibrinogen, prothrombin time, thrombin time, lactate dehydrogenase, and squamous cell carcinoma antigen were evaluated. Prothrombin time (hazard ratio = 1.825; P = 0.006) and plasma D-dimer levels (hazard ratio = 2.179; P = 0.036) were identified as significant independent predictors of overall survival. Patients with elevated D-dimer levels had a significantly shorter overall survival compared with those with low-D-dimer levels ( |
| Databáze: | OpenAIRE |
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