Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes
| Autor: | Armando Reyes-Engel, Kenny A. Rodriguez-Wallberg, Arturo R. Palomares, Maximiliano Ruiz-Galdón, Adrián Alberto Castillo-Domínguez |
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| Rok vydání: | 2021 |
| Předmět: |
p53
Adult Genotype Pregnancy Rate medicine.medical_treatment SNP Single-nucleotide polymorphism Fertilization in Vitro Polymorphism Single Nucleotide Pregnancy Maintenance Miscarriage Andrology MDM4 Endometrium Egg donation Pregnancy Genetics medicine Humans Embryo Implantation Alleles Genetic Association Studies Genetics (clinical) In vitro fertilisation business.industry Obstetrics and Gynecology General Medicine Embryo Transfer medicine.disease Implantation Tissue Donors Embryo transfer Genotype frequency Abortion Spontaneous Reproductive Medicine Case-Control Studies Receptivity USP7 Oocytes Female Tumor Suppressor Protein p53 business Infertility Female Signal Transduction Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics |
| ISSN: | 1573-7330 1058-0468 |
| DOI: | 10.1007/s10815-021-02324-9 |
| Popis: | Purpose Single-nucleotide polymorphisms (SNPs) in the p53 pathways have shown to play a role in endometrial receptivity and implantation in infertile women undergoing in vitro fertilization (IVF). The present study aimed to assess the influence of these gene variants over pregnancy success through a receptivity model in recipients of egg donation treatments, when factors such as age and quality of the oocytes are standardized. Methods A nested case–control study was performed on 234 female patients undergoing their first fresh IVF treatment as recipients of donor oocytes. Genotyping of TP53 Arg72Pro (rs1042522), LIF (rs929271), MDM4 (rs1563828), and USP7 (rs1529916) SNPs in the recipients allowed comparison of allele and genotype frequencies and their association with the IVF treatment outcome. Results Grouped by genotypes, patients showed differences in IVF outcomes after the embryo transfer. Arg72Pro (rs1042522) gene variant was associated to changes in implantation and clinical pregnancy rates. The polymorphisms USP7 (rs1529916) and MDM4 (rs1563828) were associated to differential ongoing pregnancy rates and variable miscarriage events, respectively. Conclusions This study highlights the association between gene polymorphisms related to P53 function and their influence over IVF reproductive outcomes. Arg72Pro variant may influence early events, as lower implantation rates were found in homozygous for Pro72 allele. By contrast, MDM4 (rs1563828) and USP7 (rs1529916) gene variants were associated with the later maintenance of pregnancy. |
| Databáze: | OpenAIRE |
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