Organoids of epithelial ovarian cancer as an emerging preclinical in vitro tool: a review
| Autor: | Dirk Timmerman, Sander Dumont, R. Heremans, Toon Van Gorp, Ignace Vergote, Ziga Jan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
endocrine system diseases Cell Culture Techniques Review Stem cells Carcinoma Ovarian Epithelial In Vitro Techniques medicine.disease_cause lcsh:Gynecology and obstetrics 03 medical and health sciences 3D cell culture 0302 clinical medicine Organoid medicine Genetics Animals Humans Epithelial ovarian cancer Diagnostics lcsh:RG1-991 Ovarian Neoplasms business.industry Obstetrics and Gynecology Cancer medicine.disease Gynecological cancer Organoids Disease Models Animal 030104 developmental biology Cell Transformation Neoplastic Oncology Drug screening 030220 oncology & carcinogenesis Cancer research Female Personalized medicine Disease Susceptibility Cell culture Therapy Stem cell Drug Screening Assays Antitumor Carcinogenesis business |
| Zdroj: | Journal of Ovarian Research Journal of Ovarian Research, Vol 12, Iss 1, Pp 1-11 (2019) |
| Popis: | Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer in developed countries, indicating the need for further research. Although current cancer models prove useful, they have major limitations. Organoids, a novel in vitro 3D cell culture technique, derived from stem cells, could provide a bridge between the current preclinical platforms. However, this technique is still in its early stages. After conducting a systematic literature search, only sixteen manuscripts concerning ovarian related organoids could be retrieved.In this review, we discuss current tumor models, including organoids and provide a comprehensive review about organoids of ovarian tissue. Potential future applications are addressed, proving organoids to be an interesting platform for modeling tumorigenesis, drug testing and screening and other applications. Recent advancements could usher in a new era of highly personalized medicine in EOC. ispartof: JOURNAL OF OVARIAN RESEARCH vol:12 issue:1 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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