Vitamin E and cancer prevention: recent advances and future potentials
| Autor: | Kedar N. Prasad, J Edwards-Prasad |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Vitamin
Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) Gene Expression Pharmacology Biology chemistry.chemical_compound Basal (phylogenetics) Mice Internal medicine Cricetinae Neoplasms medicine Tumor Cells Cultured Animals Humans Vitamin E Drug Interactions Anticarcinogen Nutrition and Dietetics Cancer prevention Biological activity In vitro Rats Endocrinology chemistry Female Cyclase activity |
| Zdroj: | Journal of the American College of Nutrition. 11(5) |
| ISSN: | 0731-5724 |
| Popis: | Many animal and in vitro experiments have shown that the supplementation of diet with vitamin E within a certain dose range reduced the risk of chemical- and radiation-induced cancers. In vitro studies revealed that alpha-tocopheryl succinate (TS) induced differentiation and growth-inhibition in certain animal and human tumor cells in culture, whereas alpha-tocopherol (alpha-T), alpha-tocopheryl acetate (alpha-TA) and alpha-tocopheryl nicotinate (alpha-TN) were ineffective, alpha-TS also reduced basal and ligand-stimulated adenylate cyclase activity, and expression of c-myc and H-ras oncogenes in certain tumor cells in culture. The relative efficacy of various forms of vitamin E in cancer prevention in animal or human models has not been evaluated. Human epidemiologic studies utilizing retrospective and prospective case-control experimental designs are not suitable for evaluating the role of vitamin E in cancer prevention due to several inherent problems associated with these methodologies. Intervention trials utilizing vitamin E with appropriate biological and statistical rationales are most suitable for testing the role of vitamin E in cancer prevention in humans. Some human trials utilizing vitamin E alone or in combination with other nutrients are in progress. |
| Databáze: | OpenAIRE |
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