Prognostic Value of High Sensitive Troponin T in Patients with Chronic Ischemic Heart Disease Undergoing Percutaneous Coronary Intervention
| Autor: | Oguz Yildirim, Halil Aktas, Murat Gul, Sinan Inci, Mustafa Demirtaş, Ali Deniz, Onur Kaypaklı, Caglar Ozmen |
|---|---|
| Přispěvatelé: | Tıp Fakültesi |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Major Adverse Cardiovascular Events business.industry High Sensitive Troponin T medicine.medical_treatment Urology Chronic Ischemic Heart Disease Percutaneous coronary intervention 030204 cardiovascular system & hematology Prognosis Chronic ischemic heart disease 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine High sensitivity troponin medicine In patient 030212 general & internal medicine Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cor et Vasa. 63:32-39 |
| ISSN: | 1803-7712 0010-8650 |
| DOI: | 10.33678/cor.2020.082 |
| Popis: | Aktaş, Halil ( Aksaray, Yazar ) Objective: Several studies have investigated different cardiac biomarkers as predictors of the prognosis after percutaneous coronary interventions (PCI) in patients with chronic ischemic heart disease; nevertheless, the results of these studies are conflicting. High sensitive troponin T (Hs-TnT) measurement is a novel and sensitive method. The aim of this study was to investigate if Hs-TnT levels are a predictor of major adverse cardiovascular events (MACE) in the first year after a successful elective PCI in patients with stable angina pectoris (SAP). Material and methods: 100 patients who presented with SAP and underwent successfully elective PCI were included in the study. Patients with elevated troponin I levels (>0.1 ng/mL) before the procedure excluded from the study. Hs-TnT levels were measured before the procedure and at 3-4 hours (h) (early period) and 12-24 hours (late period) after the procedure and Hs-TnT level >14 pg/mL was considered positive. The incidence of MACE during the first year was recorded. Results: Hs-TnT levels were positive in 36% of the patients in the early period and in 54% of the patients in the late period. The incidence rate of MACE for the first year was significantly higher in the patients with positive Hs-TnT levels in the early period but not the late period (36.1% vs. 15.6%; p = 0.026) and logistic regression analysis yielded an odds ratio of 3.36. Conclusion: Hs-TnT levels measured 3-4 h after a successful elective PCI in patients with SAP can predict the incidence of MACE within the first year. Nonetheless, these results must be corroborated by other larger studies. |
| Databáze: | OpenAIRE |
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