Epidermal Growth Factor Receptor and Estrogen and Progesterone Receptors in Breast Cancers of Premenopausal and Postmenopausal Patients
| Autor: | Elzbieta Skasko, Beata Bielińska, Paszko Z, Anna Kluska |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.drug_class Estrogen receptor Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Humans Medicine Epidermal growth factor receptor Receptor Estrogen receptor beta Aged Aged 80 and over biology business.industry Cell Membrane Age Factors General Medicine Middle Aged medicine.disease ErbB Receptors Postmenopause Endocrinology Premenopause Receptors Estrogen Oncology Membrane protein Estrogen 030220 oncology & carcinogenesis biology.protein Female Receptors Progesterone business Estrogen receptor alpha |
| Zdroj: | Tumori Journal. 80:56-60 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089169408000111 |
| Popis: | Aims and backroundThe purpose of our research was to investigate the relations between the levels of epidermal growth factor receptor and estrogen and progesterone receptors in breast cancers of premenopausal and postmenopausal Polish women.MethodsCell membrane levels of epidermal growth factor receptor (EGF-R), and cytosol (c) estrogen (ER) and progesterone (PR) receptors were determined in 221 specimens of primary breast cancers. ERc and PRc were assayed using the dextran-coated charcoal procedure, and EGF-R were assayed by the radioligand method of specific saturation of the crude membrane fraction with125I-EGFResultsA statistically significant inverse correlation was found in all tumors between the concentrations of EGF-R and ERc, whereas for PRc significance of this correlation was not fully confirmed. ERc concentrations in tumors were positively correlated with age of patients, whereas EGF-R and PRc were not. In all, in premenopausal, and in postmenopausal EGF-R-positive tumors (≥ 10 fmol/mg of membrane protein), mean concentrations of ERc did not differ significantly. These groups of tumors seem to be homogeneous with respect to ERc concentrations. In EGF-R-negative (< 10 fmol/mg of membrane protein) postmenopausal tumors, the mean ERc concentration was significantly higher than in premenopausal tumors, hence these groups of tumors appear to be heterogeneous with regard to ERc con tens:ConclusionsThe present findings may have significance in differentiation of postmenopausal breast cancer. |
| Databáze: | OpenAIRE |
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