Insulin resistance and outcome in bipolar disorder
| Autor: | Claire Slaney, Martin Alda, Julie Garnham, Tomas Hajek, Cynthia V. Calkin, M. Claire O’Donovan, Martina Ruzickova, Rudolf Uher |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Bipolar Disorder Adolescent Lithium (medication) medicine.medical_treatment Type 2 diabetes Lithium Young Adult 03 medical and health sciences 0302 clinical medicine Insulin resistance Antimanic Agents Internal medicine medicine Humans Insulin Bipolar disorder Antipsychotic Aged Aged 80 and over Odds ratio Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Cross-Sectional Studies Treatment Outcome Endocrinology Diabetes Mellitus Type 2 Case-Control Studies Disease Progression Female Insulin Resistance Psychology Body mass index 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | British Journal of Psychiatry. 206:52-57 |
| ISSN: | 1472-1465 0007-1250 |
| Popis: | BackgroundLittle is known about the impact of insulin resistance on bipolar disorder.AimsTo examine the relationships between insulin resistance, type 2 diabetes and clinical course and treatment outcomes in bipolar disorder.MethodWe measured fasting glucose and insulin in 121 adults with bipolar disorder. We diagnosed type 2 diabetes and determined insulin resistance. The National Institute of Mental Health Life Chart was used to record the course of bipolar disorder and the Alda scale to establish response to prophylactic lithium treatment.ResultsPatients with bipolar disorder and type 2 diabetes or insulin resistance had three times higher odds of a chronic course of bipolar disorder compared with euglycaemic patients (50% and 48.7% respectively v. 27.3%, odds ratio (OR) = 3.07, P = 0.007), three times higher odds of rapid cycling (38.5% and 39.5% respectively v. 18.2%, OR = 3.13, P = 0.012) and were more likely to be refractory to lithium treatment (36.8% and 36.7% respectively v. 3.2%, OR = 8.40, PConclusionsComorbid insulin resistance may be an important factor in resistance to treatment in bipolar disorder. |
| Databáze: | OpenAIRE |
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