Anti-gout Potential of Malaysian Medicinal Plants
| Autor: | Fazleen I. Abu Bakar, Mohd F. Abu Bakar, Asmah Rahmat, Norazlin Abdullah, Siti F. Sabran, Susi Endrini |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
musculoskeletal diseases
congenital hereditary and neonatal diseases and abnormalities Mini Review phytochemical 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cassia Kaempferia galanga Pharmacology (medical) Chrysanthemum indicum Medicinal plants Malaysian medicinal plants Artemisia vulgaris Pharmacology biology Traditional medicine anti-gout lcsh:RM1-950 nutritional and metabolic diseases food and beverages in vitro biology.organism_classification 0104 chemical sciences xanthine oxidase inhibition 010404 medicinal & biomolecular chemistry in vivo lcsh:Therapeutics. Pharmacology chemistry Phytochemical 030220 oncology & carcinogenesis Uric acid Cinnamomum |
| Zdroj: | Frontiers in Pharmacology Frontiers in Pharmacology, Vol 9 (2018) |
| ISSN: | 1663-9812 |
| Popis: | Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. |
| Databáze: | OpenAIRE |
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