No causal association identified for human papillomavirus infections in lung cancer
| Autor: | Vladimir Janout, Christine Carreira, Michael Pawlita, Devasena Anantharaman, H. Bas Bueno-de-Mesquita, Lenka Foretová, Massimo Tommasino, Paul Brennan, Françoise Clavel-Chapelon, Dana Mates, Eleonora Fabianova, J. Ramón Quirós, Behnoush Abedi-Ardekani, Mikael Johansson, Jolanta Lissowska, Vittorio Krogh, David Zaridze, Gordana Halec, Elisabete Weiderpass, Peter Rudnai, Neonila Szeszenia-Dabrowska, H. Boeing, Mattias Johansson, Anastasia Kotanidou, Anne Tjønneland, Tarik Gheit, Tim Waterboer, Ghislaine Scelo, Ruth C. Travis, Sandrine McKay-Chopin, Anush Mukeria, Vladimir Bencko |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Antibodies Viral medicine.disease_cause Internal medicine medicine Humans Prospective Studies Human papillomavirus Lung cancer Papillomaviridae Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Human papillomavirus 16 Lung Human papillomavirus 18 Human papillomavirus 11 business.industry Papillomavirus Infections Cancer virus diseases Oncogene Proteins Viral Middle Aged respiratory system Human papillomavirus 6 medicine.disease female genital diseases and pregnancy complications Neoplasm Proteins respiratory tract diseases medicine.anatomical_structure Causal association DNA Viral RNA Viral Female Carcinogenesis business |
| Zdroj: | Cancer research. 74(13) |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Human papillomavirus (HPV) infections have been implicated in lung carcinogenesis, but causal associations remain uncertain. We evaluated a potential causal role for HPV infections in lung cancer through an analysis involving serology, tumor DNA, RNA, and p16 protein expression. Association between type-specific HPV antibodies and risk of lung cancer was examined among 3,083 cases and 4,328 controls in two case–control studies (retrospective) and one nested case–control study (prospective design). Three hundred and thirty-four available tumors were subjected to pathologic evaluation and subsequent HPV genotyping following stringent conditions to detect all high-risk and two low-risk HPV types. All HPV DNA-positive tumors were further tested for the expression of p16 protein and type-specific HPV mRNA. On the basis of the consistency of the results, although HPV11 and HPV31 E6 antibodies were associated with lung cancer risk in the retrospective study, no association was observed in the prospective design. Presence of type-specific antibodies correlated poorly with the presence of the corresponding HPV DNA in the tumor. Although nearly 10% of the lung tumors were positive for any HPV DNA (7% for HPV16 DNA), none expressed the viral oncogenes. No association was observed between HPV antibodies or DNA and lung cancer survival. In conclusion, we found no supportive evidence for the hypothesized causal association between HPV infections and lung cancer. Cancer Res; 74(13); 3525–34. ©2014 AACR. |
| Databáze: | OpenAIRE |
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