Are high-frequency (600Hz) oscillations in human somatosensory evoked potentials due to phase-resetting phenomena?
| Autor: | G. Waterstraat, Gabriel Curio, Bartosz Telenczuk, Tommaso Fedele, Hans J. Scheer, Martin Burghoff |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male media_common.quotation_subject Phase (waves) Electroencephalography Wavelet Evoked Potentials Somatosensory Physiology (medical) medicine Humans Contrast (vision) Noise level media_common Physics Communication medicine.diagnostic_test business.industry Somatosensory Cortex Middle Aged Electric Stimulation Sensory Systems Median Nerve medicine.anatomical_structure Neurology Somatosensory evoked potential Scalp Neurology (clinical) business Neuroscience |
| Zdroj: | Clinical Neurophysiology. 123:2064-2073 |
| ISSN: | 1388-2457 |
| Popis: | Objective Median nerve somatosensory evoked potentials (SEP) contain a brief oscillatory wavelet burst at about 600 Hz ( σ -burst) superimposed on the initial cortical component (N20). While invasive single-cell recordings suggested that this burst is generated by increased neuronal spiking activity in area 3b, recent non-invasive scalp recordings could not reveal concomitant single-trial added-activity, suggesting that the SEP burst might instead be generated by phase-reset of ongoing high-frequency EEG. Here, a statistical model and exemplary data are presented reconciling these seemingly contradictory results. Methods A statistical model defined the conditions required to detect added-activity in a set of single-trial SEP. Its predictions were tested by analyzing human single-trial scalp SEP recorded with custom-made low-noise amplifiers. Results The noise level in previous studies did not allow to detect single-trial added-activity in the period concomitant with the trial-averaged σ -burst. In contrast, optimized low-noise recordings do reveal added-activity in a set of single-trials. Conclusions The experimental noise level is the decisive factor determining the detectability of added-activity in single-trials. A low-noise experiment provided direct evidence that the SEP σ -burst is at least partly generated by added-activity matching earlier invasive single-cell recordings. Significance Quantitative criteria are provided for the feasibility of single-trial detectability of band-limited added-activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect