Resistance Exercise Improves Spatial Learning Ability Through Phosphorylation of 5’-Adenosine Monophosphate-Activated Protein Kinase in Parkinson Disease Mice
| Autor: | Kim, Sang-Hoon, Hwang, Lakkyong, Jin, Jun-Jang, Ko, Il-Gyu, Kim, Yong Bog, Yoon, Hye-Sun, Baek, Seung-Soo |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Levodopa Urology Morris water navigation task Tropomyosin receptor kinase B parkinson disease Neurotrophic factors Internal medicine medicine Protein kinase A Brain-derived neurotrophic factor business.industry brain-derived neurotrophic factor spatial learning ability AMPK Diseases of the genitourinary system. Urology resistance exercise Endocrinology Neurology 5’-adenosine monophosphate-activated protein kinase Phosphorylation Original Article RC870-923 Neurology (clinical) business medicine.drug |
| Zdroj: | International Neurourology Journal, Vol 25, Iss Suppl 2, Pp S55-62 (2021) International Neurourology Journal |
| ISSN: | 2093-6931 |
| DOI: | 10.5213/inj.2142336.168 |
| Popis: | Purpose: Exercise is a representative noninvasive treatment that can be applied to various diseases. We studied the effect of resistance exercise on motor function and spatial learning ability in Parkinson disease (PD) mice.Methods: The rotarod test and beam walking test were conducted to evaluate the effect of resistance exercise on motor function, and the Morris water maze test was conducted to examine the effect of resistance exercise on spatial learning ability. The effect of resistance exercise on brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) expression and 5’-adenosine monophosphate-activated protein kinase (AMPK) phosphorylation was investigated by Western blot analysis. New cell generation was confirmed by immunohistochemistry for 5-bromo-2’-deoxyuridine.Results: Resistance exercise improved coordination, balance, and spatial learning ability in PD mice. Resistance exercise enhanced new cell production, BDNF and TrkB expression, and AMPK phosphorylation in PD mice. The effect of such resistance exercise was similar to that of levodopa application.Conclusions: In PD-induced mice, resistance exercise enhanced AMPK phosphorylation to increase BDNF expression and new neuron generation, thereby improving spatial learning ability. Resistance exercise is believed to help improve symptoms of PD. |
| Databáze: | OpenAIRE |
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