Fine-needle aspiration cytology of an endometrioid-like variant of yolk sac tumor
| Autor: | J C Hawk rd, J W Strong, A S Baker, G F Worsham, Austin Rm |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Adenocarcinoma Pathology and Forensic Medicine Embryonal carcinoma Immunoenzyme Techniques Testicular Neoplasms Antineoplastic Combined Chemotherapy Protocols medicine Mesonephroma Humans Testicular Yolk Sac Tumor Retroperitoneal Neoplasms Yolk sac Hyaline Germ cell neoplasm business.industry Biopsy Needle Teratoma Neoplasms Second Primary General Medicine Anatomy Endodermal sinus tumor medicine.disease Abdominal mass medicine.anatomical_structure Chemotherapy Adjuvant Immature teratoma alpha-Fetoproteins medicine.symptom business |
| Zdroj: | Diagnostic cytopathology. 8(6) |
| ISSN: | 8755-1039 |
| Popis: | A 36-year-old male with a history of immature teratoma and embryonal carcinoma of the testis was admitted to the hospital for abdominal pain and fever. A CT scan revealed a large right abdominal mass. The patient's serum alpha-fetoprotein (AFP) was 46.8 ng/ml (reference < 25 ng/ml). Fine-needle aspiration (FNA) of the mass revealed malignant glandular cells. Chemotherapy was instituted, followed by resection of the large abdominal mass. The tumor was grossly encapsulated, consisting of large areas of necrotic, hemorrhagic tissue surrounded by smaller, multiloculated cysts. Microscopically, the tumor had a villoglandular pattern and variably stratified tall columnar cells. A prominent feature of the columnar cells was supranuclear and subnuclear vacuolization. Intracytoplasmic PAS-positive, diastase-resistant hyaline globules were occasionally present. AFP by immunoperoxidase was prominent within the tumor. This recurrence of the previously diagnosed testicular teratoma with embryonal carcinoma represents a yolk sac tumor with components strongly resembling endometrioid carcinoma, a variant only recently described in eight cases of ovarian origin (Clement et al.: Am J Surg Pathol 1987; 11(10):767-778). We believe this is the first reported case of an endometrioid-like variant of testicular yolk sac tumor and also the first report of the FNA cytology findings in this variant. |
| Databáze: | OpenAIRE |
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