Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study
| Autor: | Doron Gothelf, Omri Weisman, Donna M. McDonald-McGinn, Raquel E. Gur, Elaine H. Zackai, Yael Guri, Carrie E. Bearden, Tara A. Niendam, Opal Y. Ousley, Monica E. Calkins, Kevin M. Antshel, Sunny X. Tang, Leila Kushan, Vandana Shashi, Tony J. Simon, Beverly S. Emanuel, Stephan Eliez, Elaine F. Walker, Stefano Vicari, Marianne Bernadette van den Bree, Joseph F. Cubells, Maria Jalbrzikowski, Stephen R. Hooper, Marie Schaer, Wendy R. Kates, Joel Stoddard, Maude Schneider, Maria Pontillo, Marco Armando, Wanda Fremont |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Psychosis medicine.medical_specialty Adolescent Population Prodromal Symptoms Comorbidity 03 medical and health sciences ddc:616.89 Young Adult 0302 clinical medicine global assessment of functioning (GAF) velocardiofacial syndrome DiGeorge syndrome structured interview for prodromal syndromes medicine DiGeorge Syndrome anxiety disorder Humans Cognitive Dysfunction Young adult education Psychiatry Child education.field_of_study Subthreshold conduction business.industry Cognition Middle Aged medicine.disease subthreshold psychotic symptoms Anxiety Disorders 030227 psychiatry Psychiatry and Mental health Psychotic Disorders IQ Attention Deficit Disorder with Hyperactivity Anxiety attention deficit hyperactivity disorder (ADHD) medicine.symptom business 030217 neurology & neurosurgery Anxiety disorder Regular Articles |
| Zdroj: | Weisman, O; Guri, Y; Gur, RE; McDonald-McGinn, DM; Calkins, ME; Tang, SX; et al.(2017). Subthreshold psychosis in 22q11.2 deletion syndrome: Multisite naturalistic study. Schizophrenia Bulletin, 43(5), 1079-1089. doi: 10.1093/schbul/sbx005. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/7bf8368m Schizophrenia Bulletin (2017) |
| ISSN: | 0586-7614 |
| DOI: | 10.1093/schbul/sbx005. |
| Popis: | © The Author 2017. Nearly one-third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder during life, most of them by early adulthood. Importantly, a fullblown psychotic episode is usually preceded by subthreshold symptoms. In the current study, 760 participants (aged 6-55 years) with a confirmed hemizygous 22q11.2 microdeletion have been recruited through 10 medical sites worldwide, as part of an international research consortium. Of them, 692 were nonpsychotic and with complete measurement data. Subthreshold psychotic symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). Nearly one-third of participants met criteria for positive subthreshold psychotic symptoms (32.8%), less than 1% qualified for acute positive subthreshold symptoms, and almost a quarter met criteria for negative/disorganized subthreshold symptoms (21.7%). Adolescents and young adults (13-25 years) showed the highest rates of subthreshold psychotic symptoms. Additionally, higher rates of anxiety disorders and attention deficit/hyperactivity disorder (ADHD) were found among the study participants with subthreshold psychotic symptoms compared to those without. Full-scale IQ, verbal IQ, and global functioning (GAF) scores were negatively associated with participants' subthreshold psychotic symptoms. This study represents the most comprehensive analysis reported to date on subthreshold psychosis in 22q11.2DS. Novel findings include age-related changes in subthreshold psychotic symptoms and evidence that cognitive deficits are associated with subthreshold psychosis in this population. Future studies should longitudinally follow these symptoms to detect whether and how early identification and treatment of these manifestations can improve long-term outcomes in those that eventually develop a psychotic disorder. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|