How do the effective bone properties evolve during normal and pathological calcification?
| Autor: | Jean-Christophe Perrin, Arnaud Bianchi, Alexandre Marano, Hervé Kempf, Cédric Laurent, Adrien Baldit, Maude Ferrari |
|---|---|
| Přispěvatelé: | Laboratoire d'Etude des Microstructures et de Mécanique des Matériaux (LEM3), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM), Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty [SDV.BIO]Life Sciences [q-bio]/Biotechnology [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging 0206 medical engineering Biomedical Engineering Bioengineering Pathologic calcification 02 engineering and technology [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC] 030218 nuclear medicine & medical imaging [SPI.MAT]Engineering Sciences [physics]/Materials [PHYS.MECA.MEMA]Physics [physics]/Mechanics [physics]/Mechanics of materials [physics.class-ph] 03 medical and health sciences 0302 clinical medicine Animal model [PHYS.MECA.STRU]Physics [physics]/Mechanics [physics]/Structural mechanics [physics.class-ph] [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] [PHYS.MECA.SOLID]Physics [physics]/Mechanics [physics]/Solid mechanics [physics.class-ph] Medicine [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph] [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials Pathological [PHYS.MECA.VIBR]Physics [physics]/Mechanics [physics]/Vibrations [physics.class-ph] [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health business.industry General Medicine [PHYS.MECA.MSMECA]Physics [physics]/Mechanics [physics]/Materials and structures in mechanics [physics.class-ph] medicine.disease 020601 biomedical engineering Skeleton (computer programming) Computer Science Applications Human-Computer Interaction business Calcification |
| Zdroj: | Computer Methods in Biomechanics and Biomedical Engineering Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis, 2020, 23 (sup1), pp.S166-S168. ⟨10.1080/10255842.2020.1813417⟩ |
| ISSN: | 1025-5842 1476-8259 |
| DOI: | 10.1080/10255842.2020.1813417⟩ |
| Popis: | International audience; Numerous diseases are associated with (or due to) a pathologic calcification of the skeleton. It may involve a defect in calcification (as in bone in osteoporotic patients) or on the contrary, an excess of calcification, or even the appearance of calcification in a normally non-calcified tissue. Understanding the effect of calcification on skeletal tissue properties is therefore a milestone to propose preventive or therapeutic strategies. In vitro studies involving murine models with normal or pathologic calcification have been used (Leroux-Berger et al. 2011) but results are generally limited to histological observations. In addition to such observations, mechanical testing may give an access to the macroscopic mechanical response of small skeletal samples and permit comparative studies, but does not provide with a characterization of local tissue properties. Alternatively, various studies (Laurent et al. 2016) have emphasized that Computed Tomography (CT) may be used to predict overall bone stiffness using subject-specific Finite Element (FE) models. FE models may then be used to identify bone properties using an inverse method, based on experimental biomechanical data, in order to identify bone properties. However, in the case of non-calcified tissue, the geometries issued from CT may be insufficient, and completed by Magnetic Resonance Imaging (MRI) (Singh et al. 2018) in order to characterize immature bone or fibrocartilage. In this study, combined CT-MRI imaging are used to characterize normal and pathologic calcification, and then enables to build subject-specific FE models of murine femurs to identify corresponding skeletal tissue properties. |
| Databáze: | OpenAIRE |
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