Involvement of the cholinergic neuronal system and benzodiazepine receptors in alcohol-induced amnesia
| Autor: | T. Kameyama, Toshitaka Nabeshima, Seiichi Ishihara, Keiko Tohyama |
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| Rok vydání: | 1991 |
| Předmět: |
Agonist
Male medicine.drug_class Physostigmine Amnesia Mice Inbred Strains behavioral disciplines and activities Chlordiazepoxide Mice Parasympathetic Nervous System mental disorders medicine Avoidance Learning Animals Memory disorder Pharmacology Benzodiazepine Ethanol business.industry GABAA receptor Bicuculline medicine.disease Receptors GABA-A nervous system diseases nervous system Cholinergic Cholinesterase Inhibitors medicine.symptom business Neuroscience psychological phenomena and processes medicine.drug |
| Zdroj: | European journal of pharmacology. 195(2) |
| ISSN: | 0014-2999 |
| Popis: | We investigated the involvement of the GABAergic and cholinergic neuronal systems and benzodiazepine (BZP) receptors in ethanol-induced amnesia using a passive avoidance task. Pretraining administration of ethanol impaired the passive avoidance response. The BZP agonist chlordiazepoxide potentiated the amnesia, while the GABA antagonists bicuculline and picrotoxin failed to affect it. The acetylcholine esterase inhibitor physostigmine partially attenuated the ethanol-induced amnesia. These results suggest that ethanol-induced amnesia is related to BZP receptors and a dysfunction of the cholinergic neuronal system. |
| Databáze: | OpenAIRE |
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