Susceptibility loci for complex regional pain syndrome
| Autor: | Bob J. van Hilten, Bart O. Roep, Arno R. van der Slik, Marius J. Giphart, Willem‐Johan T. van de Beek |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Adolescent Genetic Linkage Genes MHC Class I Locus (genetics) Neurological disorder Human leukocyte antigen Bioinformatics Chromosomes Central nervous system disease Gene Frequency medicine Humans Genetic Predisposition to Disease HLA-DR Serological Subtypes Dystonia Involuntary movement Chromosome Mapping HLA-DR Antigens Middle Aged medicine.disease Anesthesiology and Pain Medicine Complex regional pain syndrome Neurology Susceptibility locus Wounds and Injuries Female Neurology (clinical) Psychology Nucleic Acid Amplification Techniques Neuroscience Complex Regional Pain Syndromes Microsatellite Repeats |
| Zdroj: | Pain. 103:93-97 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/s0304-3959(02)00444-x |
| Popis: | An association between HLA-DR13 and patients with complex regional pain syndrome (CRPS) who progressed towards multifocal or generalized tonic dystonia was recently reported. We now report on a new locus, centromeric in HLA-class I, which was significantly associated with a spontaneous development of CRPS, suggesting an interaction between trauma severity and genetic factors conferring CRPS susceptibility. Additionally, an association with the D6S1014 locus was found, supporting the previous finding of an association with HLA-DR13. |
| Databáze: | OpenAIRE |
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