Apolipoprotein E promoter genotypes are not associated with white matter hyperintensity development in high-altitude careers
| Autor: | Paul M. Sherman, James C. Baldwin, John T. Sladky, Richard R Chapleau, CharLee A. Martin, Summer R. Hughes, Michael Grinkemeyer |
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| Rok vydání: | 2019 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Genotype lcsh:Medicine Biology Polymorphism Single Nucleotide General Biochemistry Genetics and Molecular Biology Cohort Studies Genotype screening 03 medical and health sciences Apolipoproteins E 0302 clinical medicine Altitude Gene Frequency Internal medicine medicine Humans 030212 general & internal medicine Occupations Promoter Regions Genetic lcsh:Science (General) lcsh:QH301-705.5 Genotyping lcsh:R General Medicine Effects of high altitude on humans Magnetic Resonance Imaging White Matter Neuroprotection Hyperintensity Research Note Military Personnel Endocrinology lcsh:Biology (General) White matter hyperintensity High altitude acclimatization Cohort lipids (amino acids peptides and proteins) 030217 neurology & neurosurgery lcsh:Q1-390 |
| Zdroj: | BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019) BMC Research Notes |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-019-4654-9 |
| Popis: | Objective This study sought to determine if there is an association between variants in the apolipoprotein E (ApoE) promoter regions and development of white matter hyperintensities (WMH) in military subjects who have been exposed to high altitude. In an earlier study, we found that ApoE status did not correlate with WMH development, and here we hypothesized that regulation of APOE protein expression may be protective. Results Our cohort of 92 subjects encountered altitude exposures above 25,000 feet mean sea level through their occupations as pilots or altitude chamber technicians. Using Taqman-style polymerase chain reaction genotyping and t-tests and two-way analyses of variance we found no significant association between ApoE promoter genotypes and the presence, volume, or quantity of WMHs after high altitude exposure. Taken together, the observations that neither ApoE genotype status nor promoter status are associated with WMH properties, we believe that the mechanism of action for developing WMH does not derive from ApoE, nor would therapies for ApoE-mediated neurodegeneration likely benefit high altitude operators. |
| Databáze: | OpenAIRE |
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