Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis
| Autor: | İlknur Keskin, Burçin Ergene Öz, Bade Cevriye Ozrenk, Hanefi Özbek, Özlem Bahadır Acıkara, Ekin Kurtul, Gülçin Saltan, Serkan Özbilgin, Mehmet Tekin, Neriman İpek Kırmızı |
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| Přispěvatelé: | [Ozbek, Hanefi] Istanbul Medipol Univ, Dept Pharmacol, Fac Med, Istanbul, Turkey -- [Acikara, Ozlem Bahadir -- Ozbilgin, Serkan -- Oz, Burcin Ergene -- Kurtul, Ekin -- Saltan, Gulcin] Ankara Univ, Dept Pharmacognosy, Fac Pharm, Ankara, Turkey -- [Keskin, Ilknur] Istanbul Medipol Univ, Dept Histol & Embryol, Fac Med, Istanbul, Turkey -- [Kirmizi, Neriman Ipek -- Ozrenk, Bade Cevriye] Istanbul Medipol Univ, Fac Med, Dept Vocat, Sch Hlth Serv, Istanbul, Turkey -- [Tekin, Mehmet] Cumhuriyet Univ, Dept Pharmaceut Bot, Fac Pharm, Sivas, Turkey, keskin, ilknur -- 0000-0002-7059-1884, Ozbek, Hanefi -- 0000-0002-8084-7855, OZBILGIN, Serkan -- 0000-0002-3945-6756, SALTAN, HAYRIYE GULCIN -- 0000-0001-6633-0713, Tekin, Mehmet -- 0000-0002-6504-2223 |
| Rok vydání: | 2017 |
| Předmět: |
Male
Antioxidant Alchemilla mollis medicine.medical_treatment Drug Evaluation Preclinical Hepatoprotective activity Histopathological examination Pharmacology Protective Agents Plant Roots 01 natural sciences Hepatoprotective Activity Diabetes Mellitus Experimental Rats Sprague-Dawley Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Hypoglycemic Agents Alchemilla biology Plant Extracts fungi food and beverages Diabetic mouse General Medicine Plant Components Aerial Alchemilla Mollis biology.organism_classification Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Antidiabetic activity Liver chemistry 030220 oncology & carcinogenesis Antidiabetic Activity Carbon tetrachloride Female |
| Zdroj: | Biomedicine & Pharmacotherapy. 86:172-176 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/j.biopha.2016.12.005 |
| Popis: | WOS: 000395523800024 PubMed ID: 27978496 Alchemilla mollis (Buser) Rothm aerial part and root methanolic-water extracts were evaluated for their hepatoprotective activity on carbon tetrachloride induced hepatotoxicity and hypoglycemic activity on alloxan-induced diabetic mice. None of the tested extracts exhibited effects on blood glucose levels. However hepatoprotective activity results have revealed that serum ALT levels were significantly lowered by both the aerial part and root extracts at doses of 100 mg/kg and 200 mg/kg. Histopathological examination showed that A. mollis aerial parts and roots induced significant recovery from cellular damage; when compared to the carbon tetrachloride group, the most significant activity was observed with A. mollis aerial part extracts at a dose of 200 mg/kg. There is evidence of a hepatoprotective activity of A. mollis on the phenolic content of the plant, especially in the case of flavonoids, which have potent antioxidant properties. (C) 2016 Elsevier Masson SAS. All rights reserved. |
| Databáze: | OpenAIRE |
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