Hypoglycemia and Dementia Risk in Older Patients with Type 2 Diabetes Mellitus: A Propensity-Score Matched Analysis of a Population-Based Cohort Study
| Autor: | Ja Young Jeon, Kwan Woo Lee, Young-Gun Kim, Hae Jin Kim, So Young Moon, Dong Gyu Park, Dae Jung Kim, Seung Jin Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Hypoglycemia Clinical Complications lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Risk Factors Internal medicine Republic of Korea mental disorders medicine Humans Hypoglycemic Agents Dementia Propensity Score Vascular dementia education Aged Retrospective Studies Aged 80 and over education.field_of_study lcsh:RC648-665 business.industry Dementia Vascular Hazard ratio Response Type 2 Diabetes Mellitus medicine.disease hypoglycemia diabetes mellitus type 2 Propensity score matching Cohort Female Original Article business dementia |
| Zdroj: | Diabetes & Metabolism Journal, Vol 44, Iss 1, Pp 125-133 (2020) Diabetes & Metabolism Journal |
| ISSN: | 2233-6087 2233-6079 |
| Popis: | BACKGROUND Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM. METHODS We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 5,966 patients who had ever experienced at least one episode of hypoglycemia were matched with those who had not, using propensity score matching. The risk of dementia was assessed through a survival analysis of matched pairs. RESULTS Patients with underlying hypoglycemic events had an increased risk for all-cause dementia, Alzheimer's dementia (AD), and vascular dementia (VaD) compared with those who had not experienced a hypoglycemic event (hazard ratio [HR], 1.254; 95% confidence interval [CI], 1.166 to 1.349; P |
| Databáze: | OpenAIRE |
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