KIR/HLA ligands immunogenetics markers associated with outcome of hepatitis B virus infection in the Bulgarian population
| Autor: | Georgi T. Popov, Viktoria Varbanova, Diana Petrova, Anastasiya Mihaylova, Elissaveta Naumova, Veneta Grigorova |
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| Rok vydání: | 2020 |
| Předmět: |
Hepatitis B virus
Genotype kir hla ligands Immunogenetics Human leukocyte antigen 030204 cardiovascular system & hematology medicine.disease_cause Ligands General Biochemistry Genetics and Molecular Biology Virus 03 medical and health sciences 0302 clinical medicine Receptors KIR medicine Humans killer immunoglobuline-like receptors Allele business.industry hepatitis b infection Liver Neoplasms medicine.disease Hepatitis B Receptors KIR2DL5 030220 oncology & carcinogenesis Hepatocellular carcinoma Case-Control Studies Immunology Medicine business KIR3DL1 |
| Zdroj: | Biomedical Papers, Vol 165, Iss 3, Pp 270-276 (2021) |
| ISSN: | 1804-7521 |
| Popis: | Background Hepatitis B virus (HBV) infection is one of the most common infections worldwide, having negative impact on world health due to the tendency for chronification with late complications such as liver cirrhosis and hepatocellular carcinoma. Natural killer (NK) cells as part of innate antiviral defense influence the clinical course of HBV infection: elimination of the virus or chronic disease. Aim Therefore, we investigated the polymorphisms of the main gene systems, regulating NK-cell function: killer cell immunoglobulin-like receptors (KIRs) and their appropriate HLA class I ligands in 144 HBV infected patients (124 chronic carriers and 20 spontaneously recoved) and 126 ethnically matched healthy controls from the Bulgarian population in a case-control study. Methods KIRs and HLA ligands were determined by PCR-SSP or PCR high-resolution typing methods. Results KIR2DL5B allele variant was significantly less frequent in spontaneously recovered (SR) patients compared to healthy controls (10.0% vs. 45.5%, Pcorr=0.006). The presence of KIR3DL1*004 allele was higher in chronic HBV carriers (CH) than in controls (33.1% vs. 17.6%, Pcorr=0.036). Additionally, SR patients differed from healthy individuals by the lower frequency of HLA-Bw4Ile80 group ligands (30.0% vs 63.7%, P=0.015). Three KIR genotypes were found more frequent in healthy in comparison with HBV infected individuals: ID2 (13.5% vs 5.6%, P=0.025), KIR genotype containing 6 activating KIRs (18.0% vs 7.6%, P=0.017), and KIR genotype composed of 4 activating and 5 inhibitory KIRs (23.8% vs 5.6%, P=0.001). Conclusion These data suggest that inherited KIR and HLA class I ligand polymorphisms may influence the clinical course of HBV infection. |
| Databáze: | OpenAIRE |
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