Impact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012
| Autor: | Florence Joly, Martine Dubois, Jeffrey S. Wefel, Michiel B. de Ruiter, Marie Lange, Janette L. Vardy, Véronique Pancré, Olivier Rigal, Bénédicte Giffard, Sanne B. Schagen, Tim A. Ahles, Brent J. Small, Johan Lefel, Hélène Castel |
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| Přispěvatelé: | Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, École nationale supérieure des sciences de l'information et des bibliothèques (ENSSIB), Université de Lyon, Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Antoni van Leeuwenhoek Hospital, University of South Florida [Tampa] (USF), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Weill Medical College of Cornell University [New York], University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), University of New South Wales [Sydney] (UNSW), Mécanismes de tumorigenèse et thérapies ciblées, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse (CRLC François Baclesse ), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of South Florida (USF), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_treatment
Antineoplastic Agents Context (language use) Neuroimaging 03 medical and health sciences [SCCO]Cognitive science 0302 clinical medicine Breast cancer Cognition Elderly Neoplasms Animals Humans Medicine Chemotherapy Cognitive rehabilitation therapy Cognitive decline General Nursing Cognitive deficit Cancer business.industry [SCCO.NEUR]Cognitive science/Neuroscience medicine.disease 3. Good health Anesthesiology and Pain Medicine 030220 oncology & carcinogenesis Neurology (clinical) Hormone therapy medicine.symptom Cognition Disorders business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Pain and Symptom Management Journal of Pain and Symptom Management, Elsevier, 2015, 50 (6), pp.830-841. ⟨10.1016/j.jpainsymman.2015.06.019⟩ Journal of Pain and Symptom Management, 2015, 50 (6), pp.830-841. ⟨10.1016/j.jpainsymman.2015.06.019⟩ |
| ISSN: | 0885-3924 |
| Popis: | Context. Although cognitive impairments have been identified in patients with nonecentral nervous system cancer, especially breast cancer, the respective roles of cancer and therapies, and the mechanisms involved in cognitive dysfunction remain unclear. Objectives. To report a state-of-the-artupdate from the International Cognitive and Cancer Task Force conference held in 2012. Methods. A report of the meeting and recent new perspectives are presented. Results. Recent clinical data support that nonecentral nervous system cancer per se may be involved in cognitive dysfunctions associated with inflammation parameters. The role of chemotherapy on cognitive decline was confirmed in colorectal and testicular cancers. Whereas the impact of hormone therapy remains debatable, some studies support a negative impact of targeted therapies on cognition. Regarding interventions, preliminary results of cognitive rehabilitation showed encouraging results. The methodology of future longitudinal studies has to be optimized by a priori end points, the use of validated test batteries, and the inclusion of control groups. Comorbidities and aging are important factors to be taken into account in future studies. Preclinical studies in animal models highlighted the role of cancer itself on cognition and support the possible benefits of prevention/care during chemotherapy. Progress in neuroimaging will help specify neural processes affected by treatments. Conclusion. Clinical data and animal models confirmed that chemotherapy induces direct cognitive deficit. The benefits of cognitive rehabilitation are still to be confirmed. Studies evaluating the mechanisms underlying cognitive impairments using advanced neuroimaging techniques integrating the evaluation of genetic factors are ongoing. (C) 2015 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved |
| Databáze: | OpenAIRE |
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