Oxidative stress and immune cell activation quantification in sepsis and non-sepsis critical care patients by neopterin/7,8-dihydroneopterin analysis
| Autor: | Stephen T. Chambers, Gregory Baxter-Parker, Geoff Shaw, Elena Moltchanova, Steven P. Gieseg, Anitra C. Carr, Ravinder Reddy Gaddam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Crystallography
business.industry Clinical Biochemistry Neopterin biomarkers medicine.disease medicine.disease_cause Biochemistry Sepsis sepsis chemistry.chemical_compound chemistry neopterin immune system diseases inflammation QD901-999 Immune Cell Activation Immunology medicine Molecular Medicine business kidney function Oxidative stress 7 8-dihydroneopterin |
| Zdroj: | Pteridines, Vol 31, Iss 1, Pp 68-82 (2020) |
| ISSN: | 2195-4720 0933-4807 |
| Popis: | Introduction: Neopterin and 7,8-dihydroneopterin are used as biomarkers of oxidative stress and inflammation, but the effect of kidney function on these measurements has not been extensively explored. We examine the levels of oxidative stress, inflammation and kidney function in intensive patients and compare them to equivalent patients without sepsis. Methods: 34 Intensive care patients were selected for the study, 14 without sepsis and 20 with. Both groups had equivalent levels of trauma, assessed by SAPS II, SOFA, and APACHE II and III scores. Plasma and urinary neopterin and total neopterin (neopterin + 7,8-dihydroneopterin) values were measured. Results: Neopterin and total neopterin were significantly elevated in urine and plasma for multiple days in sepsis versus non-sepsis patients. Plasma neopterin and total neopterin have decreasing relationships with increased eGFR (p Conclusion: Sepsis patients present with greater levels of oxidative stress and immune system activation than non-sepsis patients of equal levels of trauma, as measured by neopterin and total neopterin. eGFR may need to be taken into account when accessing the level of inflammation from urinary neopterin measurements. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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