Microsleep versus Sleep Onset Latency during Maintenance Wakefulness Tests: Which One Is the Best Marker of Sleepiness?
| Autor: | Pierre Le Cam, Pierre Pradat, Emeric Stauffer, Frédéric Gormand, Ludivine Des Champs de Boishebert, Thierry Petitjean, Hélène Bastuji, Laure Peter-Derex, François Ricordeau |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
polysomnography sleep latency sleepiness wakefulness Maintenance Wakefulness Test Microsleep Polysomnography Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine General Environmental Science Receiver operating characteristic medicine.diagnostic_test business.industry Epworth Sleepiness Scale medicine.disease respiratory tract diseases Obstructive sleep apnea 030228 respiratory system Cardiology General Earth and Planetary Sciences Medicine Wakefulness Sleep onset latency Sleep onset business human activities 030217 neurology & neurosurgery |
| Zdroj: | Clocks & Sleep Clocks & Sleep, Vol 3, Iss 16, Pp 259-273 (2021) Clocks & Sleep; Volume 3; Issue 2; Pages: 259-273 |
| ISSN: | 2624-5175 |
| Popis: | The interpretation of the Maintenance Wakefulness Test (MWT) relies on sleep onset detection. However, microsleeps (MSs), i.e., brief periods of sleep intrusion during wakefulness, may occur before sleep onset. We assessed the prevalence of MSs during the MWT and their contribution to the diagnosis of residual sleepiness in patients treated for obstructive sleep apnea (OSA) or hypersomnia. The MWT of 98 patients (89 OSA, 82.6% male) were analyzed for MS scoring. Polysomnography parameters and clinical data were collected. The diagnostic value for detecting sleepiness (Epworth Sleepiness Scale > 10) of sleep onset latency (SOL) and of the first MS latency (MSL) was assessed by the area under the receiver operating characteristic (ROC) curve (AUC, 95% CI). At least one MS was observed in 62.2% of patients. MSL was positively correlated with SOL (r = 0.72, p < 0.0001) but not with subjective scales, clinical variables, or polysomnography parameters. The use of SOL or MSL did not influence the diagnostic performance of the MWT for subjective sleepiness assessment (AUC = 0.66 95% CI (0.56, 0.77) versus 0.63 95% CI (0.51, 0.74)). MSs are frequent during MWTs performed in patients treated for sleep disorders, even in the absence of subjective sleepiness, and may represent physiological markers of the wake-to-sleep transition. |
| Databáze: | OpenAIRE |
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