Allopurinol and glutamine attenuate bacterial translocation in chronic portal hypertensive and common bile duct ligated growing rats
| Autor: | Gerhardt Steinwender, Manfred Ratschek, Michael E. Höllwarth, P. Pesendorfer, G. Schimpl, G Feierl |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Allopurinol Glutamine medicine.medical_treatment Chromosomal translocation Gastroenterology Rats Sprague-Dawley Lipid peroxidation Random Allocation chemistry.chemical_compound Ileum Malondialdehyde Internal medicine Hypertension Portal medicine Animals Enzyme Inhibitors Ligation Peroxidase Common Bile Duct Analysis of Variance Laparotomy Chemotherapy Common bile duct business.industry Cholestasis Extrahepatic medicine.disease Rats Endocrinology medicine.anatomical_structure chemistry Bacterial Translocation Chronic Disease Portal hypertension business Research Article medicine.drug |
| Zdroj: | Gut. 39:48-53 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.39.1.48 |
| Popis: | BACKGROUND: Spontaneous bacterial infections and septicaemia result in morbidity and mortality in patients with portal hypertension and obstructive jaundice. AIM: The aim of this study in rats was to investigate the incidence of bacterial translocation in portal hypertension and obstructive jaundice, and to evaluate the effects of allopurinol and glutamine. METHODS: Rats were subjected to sham laparotomy (SL), portal hypertension (PH) by calibrated stenosis of the portal vein, and common bile duct ligation (CBDL). Animals of each group were either treated with allopurinol (50 mg/kg twice a week), glutamine (1 g/kg/d), and allopurinol and glutamine. RESULTS: After four weeks, significant bacterial translocation in the untreated PH and CBDL rats occurred. Intestinal mucosal malondialdehyde concentrations (MDA), as an indicator for lipid peroxidation, and myeloperoxidase activity (MPO) released from activated neutrophils were also significantly increased (p < 0.01). Allopurinol and glutamine in PH and CBDL rats improved bacterial translocation, and decreased MDA and MPO values (p < 0.01). CONCLUSION: In PH and CBDL rats significant bacterial translocation, ileal mucosal lipid peroxidation, and neutrophil derived MPO activity occurred. Allopurinol and glutamine significantly reduced bacterial translocation, as well as ileal mucosal MDA and MPO activities. |
| Databáze: | OpenAIRE |
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