The effectiveness of manipulation of fingers with Dupuytren's contracture 7 days after collagenase clostridial histolyticum injection
| Autor: | Warren M. Rozen, Bethany Reynolds, David J. Hunter-Smith, Vicky Tobin, Julian A. Smith |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Collagenase injection Outcome measures medicine.disease Clinical success Tendon Surgery Dupuytren Contracture Fingers medicine.anatomical_structure Under local anaesthesia Microbial Collagenase Treatment Outcome Tendon Injuries medicine Collagenase Humans Collagenases Dupuytren's contracture business Adverse effect medicine.drug |
| Zdroj: | The Journal of hand surgery, European volume. 45(3) |
| ISSN: | 2043-6289 |
| Popis: | Timing of manipulation of digits after collagenase injection for Dupuytren’s disease varies and often takes place within the first few days post-injection. We prospectively investigated the effectiveness of performing manipulation under local anaesthesia 7 days after injection in 100 patients. Demographic data, passive extension deficit, and patient-reported outcome measures were recorded before collagenase injection. Four to 7 weeks after manipulation, passive extension deficit and patient-reported outcome measures improved significantly without the development of any tendon ruptures. Clinical success was achieved in 41% and clinical improvement in 76% of the patients. Adverse events were reported by 85%. The outcomes were comparable with studies with early manipulation, and demonstrate a safe and effective variation to current protocols. We conclude that delaying manipulation to 7 days after collagenase injection is safe and efficient, which allows for flexibility in clinical appointments without negatively affecting outcome. Level of evidence: III |
| Databáze: | OpenAIRE |
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