Effects of Selected Minerals on Leptin Secretion in Streptozotocin-lnduced Hyperglycemic Mice
| Autor: | Ming-Der Chen, Yuh-Min Song, Pi-Yao Lin, Paul S. Alexander, Vivian C. Yang |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Glucose
Leptin Male medicine.medical_specialty Lithium (medication) chemistry.chemical_element Adipose tissue 030209 endocrinology & metabolism Zinc Lithium Streptozocin General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Magnesium Vanadate Secretion Minerals Interleukin-6 Tumor Necrosis Factor-alpha Chemistry Streptozotocin Mice Inbred C57BL Endocrinology Adipose Tissue Hyperglycemia Lactates Tumor necrosis factor alpha Vanadates medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 226:836-840 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.1177/153537020122600905 |
| Popis: | The effects of lithium, magnesium, vanadate, and zinc on leptinemia and leptin secretion by adipose tissue were investigated in streptozotocin- (STZ) induced hyperglycemic mice. After the administration of studied minerals in drinking water for 4 weeks, fasting serum leptin concentrations were elevated, accompanied by normoglycemia in STZ-injected mice, regardless which mineral was provided (P < 0.05). However, the in vitro administration of lithium, magnesium, and vanadate did not significantly influence the leptin secretion of adipose tissue. A low zinc treatment (0.1 mM) augmented, whereas both a pharmacological treatment of zinc (1 mM) and zinc depletion (1 mM TPEN) attenuated, leptin secretion (P < 0.05). The present study shows that STZ-induced hyperglycemic mice have hypoleptinemia and reduced leptin secretion by adipose tissue. Moreover, these defects can be improved by a moderate zinc administration. |
| Databáze: | OpenAIRE |
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