Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
| Autor: | Lee L. Rubin, Sean M. Buchanan, Richard C. Krolewski, Ceren Ozek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Aging Neurogenesis Central nervous system Subventricular zone Hippocampus lcsh:Medicine Hippocampal formation Biology Blood–brain barrier Article 03 medical and health sciences Mice 0302 clinical medicine Neural Stem Cells medicine Animals Regeneration lcsh:Science Cerebral Cortex Neurons Multidisciplinary lcsh:R Brain Endothelial Cells Neural stem cell Growth Differentiation Factors Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure GDF11 Bone Morphogenetic Proteins lcsh:Q Female Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) |
| ISSN: | 2045-2322 |
| Popis: | Aging is the biggest risk factor for several neurodegenerative diseases. Parabiosis experiments have established that old mouse brains are improved by exposure to young mouse blood. Previously, our lab showed that delivery of Growth Differentiation Factor 11 (GDF11) to the bloodstream increases the number of neural stem cells and positively affects vasculature in the subventricular zone of old mice. Our new study demonstrates that GDF11 enhances hippocampal neurogenesis, improves vasculature and increases markers of neuronal activity and plasticity in the hippocampus and cortex of old mice. Our experiments also demonstrate that systemically delivered GDF11, rather than crossing the blood brain barrier, exerts at least some of its effects by acting on brain endothelial cells. Thus, by targeting the cerebral vasculature, GDF11 has a very different mechanism from that of previously studied circulating factors acting to improve central nervous system (CNS) function without entering the CNS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|