Neurocognition in Post-Treatment Lyme Disease and Major Depressive Disorder
| Autor: | Kathy M. Corbera, Marianne Gorlyn, John G. Keilp, J. John Mann, Maria A. Oquendo, Brian A. Fallon |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 050103 clinical psychology Wechsler Memory Scale medicine.medical_specialty Neuropsychological Tests Audiology behavioral disciplines and activities Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders Humans Medicine Verbal fluency test Attention Cognitive Dysfunction 0501 psychology and cognitive sciences Psychomotor learning Depressive Disorder Major Post-Lyme Disease Syndrome Language Tests business.industry Working memory 05 social sciences Wechsler Scales Neuropsychology Wechsler Adult Intelligence Scale General Medicine Middle Aged medicine.disease Psychiatry and Mental health Clinical Psychology Memory Short-Term Neuropsychology and Physiological Psychology Case-Control Studies Major depressive disorder Female business Neurocognitive Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Archives of Clinical Neuropsychology. 34:466-480 |
| ISSN: | 1873-5843 |
| DOI: | 10.1093/arclin/acy083 |
| Popis: | Objective Neurocognitive dysfunction in patients with residual or emergent symptoms after treatment for Lyme Disease is often attributed to comorbid depression. In this study, patients with Post-Treatment Lyme Disease Syndrome (PTLDS) were compared to patients with Major Depressive Disorder (MDD), as well as healthy comparison subjects (HC), on neurocognitive measures administered through the same laboratory, to determine if patterns of performance were similar. Methods Two analyses were conducted. First, performance on the Wechsler Adult Intelligence Scale (WAIS-III) and on subtests from the Wechsler Memory Scale (WMS-III) was compared among the groups. Second, comparable subgroups of PTLDS and MDD patients with at least one low WMS-III score were compared on an additional set of measures assessing motor function, psychomotor performance, attention, memory, working memory, and language fluency, to determine if the overall profile of performance was similar in the two subgroups. Results In the first analysis, PTLDS patients performed more poorly than both MDD and HC on tasks assessing verbal abilities, working memory, and paragraph learning. Processing speed in the two patient groups, however, was equally reduced. In the second analysis, MDD patients with low WMS-III exhibited concomitantly greater difficulties in psychomotor speed and attention, while low-WMS-III PTLDS patients exhibited greater difficulties in language fluency. Conclusions MDD and PTLDS can be confused neuropsychologically because both exhibit similar levels of psychomotor slowing. However, problems on memory-related tasks, though mild, are more pronounced in PTLDS. PTLDS patients with poorer memory also exhibit poorer language fluency, and less deficit in processing speed and attention compared to MDD. |
| Databáze: | OpenAIRE |
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