Defense reaction induced by microinjections of bicuculline into the inferior colliculus
| Autor: | Abdallah Bagri, P. C. L. Borges, Marcus Lira Brandão, Norberto Cysne Coimbra, Carlos Tomaz |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Telencephalon Inferior colliculus medicine.medical_specialty Central nervous system Experimental and Cognitive Psychology Motor Activity Bicuculline Inhibitory postsynaptic potential Tonic (physiology) Behavioral Neuroscience GABA receptor Escape Reaction Internal medicine Neural Pathways medicine Animals Microinjection Brain Mapping Chemistry Rats Inbred Strains Receptors GABA-A Inferior Colliculi Rats Endocrinology medicine.anatomical_structure nervous system Microinjections Arousal Neuroscience medicine.drug |
| Zdroj: | Physiology & Behavior. 44:361-365 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/0031-9384(88)90038-8 |
| Popis: | Behavioral and autonomic effects of microinjections of bicuculline--a GABA receptor antagonist--into ventral aspects of the inferior colliculus (IC) produced a behavioral activation together with jumps. This activation was similar to escape behavior that has been induced from periventricular structures although it was neither as explosive as that observed from the dorsal periaqueductal gray matter (DPAG) nor as coordinated as that obtained from the medial hypothalamus (MH). In anesthetized rats, microinjection of bicuculline into the IC produced a clear rise in mean arterial blood pressure and in heart rate. These effects reached a maximum after 10 min and subsided within 20 min after injection. GABA receptor blockade in the IC of detelencephalated rats also resulted in escape behavior qualitatively similar to that observed in intact animals. These results suggest that in addition to the central gray and medial hypothalamus, GABA also exerts a tonic inhibitory action on neurons of the IC implicated in the generation or elaboration of aversive responses. |
| Databáze: | OpenAIRE |
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