SUICIDAL GENETIC ELEMENTS AND THEIR USE IN BIOLOGICAL CONTAINMENT OF BACTERIA

Autor:	Juan L. Ramos, Lars Boe, Kristensen Claus Sternberg, Asim K. Bej, Lars Bogø Jensen, Michael Givskov, Søren Molin
Rok vydání:	1993
Předmět:	Containment (computer programming) Bacteria Genes Bacterial business.industry Genes Lethal Environmental ethics Containment of Biohazards Biology business Microbiology Biotechnology
Zdroj:	Annual Review of Microbiology. 47:139-166
ISSN:	1545-3251 0066-4227
DOI:	10.1146/annurev.mi.47.100193.001035
Popis:	The potential risks of unintentional releases of genetically modified organisms, and the lack of predictable behavior of these in the environment, are the subject of considerable concern. This concern is accentuated in connection with the next phase of gene technology comprising deliberate releases. The possibilities of reducing such potential risks and increasing the predictability of the organisms are discussed for genetically engineered bacteria. Different approaches towards designing disabled strains without seriously reducing their beneficial effects are presented. Principally two types of strain design are discussed: actively contained bacteria based on the introduction of controlled suicide systems, and passively contained strains based on genetic interference with their survival under environmental-stress conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c42a620775552d53737795c6e3341ba https://doi.org/10.1146/annurev.mi.47.100193.001035 Zobrazit plný text záznamu