Bilberry anthocyanin extract promotes intestinal barrier function and inhibits digestive enzyme activity by regulating the gut microbiota in aging rats
| Autor: | Tao Wu, Jing Li, Xiaoling Lyu, Wang Xuening, Guiyun Chen, Na Li |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Bilberry Vaccinium myrtillus Gut flora Anthocyanins Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Lactobacillus Animals Humans Food science Barrier function 030109 nutrition & dietetics biology Bacteria Plant Extracts fungi Lachnospiraceae food and beverages General Medicine biology.organism_classification Fatty Acids Volatile Enzymes Gastrointestinal Microbiome Rats Intestines 030104 developmental biology chemistry Anthocyanin Digestive enzyme biology.protein Female Bacteroides Food Science |
| Zdroj: | Foodfunction. 10(1) |
| ISSN: | 2042-650X |
| Popis: | This study was aimed at understanding potential mechanisms regarding bilberry anthocyanin extract consumption and healthy aging and the effects on intestinal barrier function and digestive enzyme activity, through regulating the gut microbiota in aging rats. Medium-dose bilberry anthocyanin extract consumption (20 mg per kg bw per day) was the optimum amount to regulate the intestinal function of aging rats. After consumption, bacteria beneficial to the intestine (Aspergillus oryzae, Lactobacillus, Bacteroides, Clostridiaceae-1, the Bacteroidales-S24-7-group and the Lachnospiraceae_NK4A136_group) were induced to grow, and harmful bacteria (Verrucomicrobia and Euryarchaeota) were inhibited. However, high-dose bilberry anthocyanin extract consumption altered some intestinally beneficial bacteria in an adverse way. There was a correlation between changes in bacterial composition and changes in short-chain fatty acids and the intestinal mucosal barrier. Bilberry anthocyanin extract consumption also decreased the activity of digestive enzymes. Our results suggest that bilberry anthocyanin extract consumption is a potential approach for assisting healthy aging. |
| Databáze: | OpenAIRE |
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