Aging and APOE‐ε4 are determinative factors of plasma Aβ42 levels
| Autor: | Takumi Nakamura, Naoko Nakahata, Mie Hirohata, Ken Itoh, Sakiko Narita, Yusuke Seino, Takeshi Kawarabayashi, Shigeyuki Nakaji, Mikio Shoji |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry General Neuroscience Amyloidosis Central nervous system Renal function Plasma levels medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology medicine.anatomical_structure Blood chemistry Internal medicine medicine Biomarker (medicine) Neurology (clinical) business 030217 neurology & neurosurgery Research Articles Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Popis: | Objective The aim of this study was to confirm determinative factors for plasma Aβ and its association with cognitive function. Methods Fasting plasma Aβ40 and Aβ42 levels were measured by ELISA in 1019 participants in the Iwaki Health Promotion Project. The relationships between plasma Aβ and health‐related items, including physical characteristics, cognitive function tests, blood chemistry, and APOE‐ε4 genotype were analyzed. Results The plasma levels of Aβ40 and Aβ42, and Aβ40/42 ratio were found to significantly increase with aging. The age‐dependent increase in Aβ42 level was significantly suppressed by APOE‐ε4. Renal function was an associated factor for the plasma Aβ40 level. The plasma Aβ42 level and Aβ40/42 ratio correlated with cognitive function. Interpretation Age and APOE‐ε4 are major determinative factors of plasma levels of Aβ42 and the Aβ40/42 ratio. These factors are critical adjustment factors for the usage of plasma Aβ as a biomarker of central nervous system amyloidosis. |
| Databáze: | OpenAIRE |
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