Controlled drug release from polymeric delivery devices III: In vitro-in vivo correlation for intravaginal release of ethynodiol diacetate from silicone devices in rabbits
| Autor: | Kenneth F. King, John Berg, Stanley E. Mares, Howard J. Lambert, Susan Huber, Yie W. Chien |
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| Rok vydání: | 1975 |
| Předmět: |
Drug
Time Factors Surface Properties media_common.quotation_subject Radioimmunoassay Silicones Serum albumin Pharmaceutical Science Cross Reactions In Vitro Techniques Pharmacology Diffusion Ethynodiol Diacetate chemistry.chemical_compound Silicone In vivo Polymer chemistry Animals media_common biology Chemistry Serum Albumin Bovine In vitro Kinetics Vagina Drug release biology.protein Female Contraceptive Devices Rabbits Norethindrone |
| Zdroj: | Journal of Pharmaceutical Sciences. 64:1776-1781 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600641108 |
| Popis: | Forty female rabbits were implanted with silicone vaginal devices containing ethynodiol diacetate for up to 8 weeks. As predicted from in vitro studies, a Q - t 1/2 (matrix-controlled) release profile was observed in vivo . The in vivo drug release profile was compared with in vitro data measured at three hydrodynamic conditions, and the diffusional resistance across the vaginal wall was estimated. Drug released from silicone devices yielded a prolonged plasma level when compared with data following intravaginal or intravenous administration of a solution dose. The rate constant for elimination was unchanged. The plasma concentration of the drug was related to the intravaginal drug release profile both theoretically and experimentally and was above the concentration required to inhibit fertilization. |
| Databáze: | OpenAIRE |
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