Periapical Microsurgery: The Effects of Locally Injected Dexamethasone on Pain, Swelling, Bruising, and Wound Healing
| Autor: | Peter Z. Tawil, Jonathan M. Reside, Elena Kan, Steven J. Card, Marcelo Santos Coelho |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Microsurgery medicine.medical_specialty Contusions medicine.medical_treatment Anti-Inflammatory Agents Dexamethasone law.invention 03 medical and health sciences symbols.namesake 0302 clinical medicine Double-Blind Method Randomized controlled trial Adrenal Cortex Hormones law medicine Edema Humans Hydrocodone Prospective Studies General Dentistry Saline Fisher's exact test Acetaminophen Inflammation Pain Postoperative Wound Healing business.industry Periapical Tissue Apicoectomy 030206 dentistry Analgesics Non-Narcotic Surgery Analgesics Opioid Drug Combinations 030220 oncology & carcinogenesis Anesthesia symbols Female business Anesthesia Local medicine.drug |
| Zdroj: | Journal of Endodontics. 42:1608-1612 |
| ISSN: | 0099-2399 |
| DOI: | 10.1016/j.joen.2016.07.021 |
| Popis: | The purpose of this prospective, double-blind, randomized clinical trial was to evaluate the postoperative healing of endodontic periapical microsurgery after local administration of dexamethasone.Sixty patients were divided into 2 groups. The dexamethasone group received a single local submucosal injection of 4 mg dexamethasone, and the placebo group received a submucosal injection of saline solution at the conclusion of standardized periapical microsurgery. Acetaminophen and hydrocodone/acetaminophen were prescribed for pain relief. A Likert-like 6-point scale was used for self-evaluation of pain, bruising, swelling, and wound healing at 24, 48, 72, 96 hours and at 1 week. The number of tablets taken was registered. Data were analyzed using the chi-square and Fisher exact tests at a significance level of P .05.No improvements in pain, bruising, and wound healing were registered at any time interval. No difference was found in the number of tablets taken for pain relief. Subjects who received the dexamethasone injection reported less swelling 24 hours after periapical microsurgery (P .05) but showed no significant benefit for the longer follow-up periods.This study shows that a 4-mg dose of dexamethasone administered through a local submucosal injection after periapical microsurgery has minimal impact on pain, bruising, and apparent wound healing at any time over a 7-day interval, and the impact on swelling seems limited. |
| Databáze: | OpenAIRE |
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