Pluripotency of mesenchymal stem cells derived from adult marrow
| Autor: | Balkrishna N. Jahagirdar, Yuehua Jiang, Walter C. Low, Aaron Lisberg, David A. Largaespada, Sara Aldrich, C. Dirk Keene, Robert E. Schwartz, R. Lee Reinhardt, Troy C. Lund, Morayma Reyes, Jingbo Du, Xilma R. Ortiz-Gonzalez, Mark Blackstad, Todd Lenvik, Catherine M. Verfaillie |
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| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Aging
Cell Transplantation Cellular differentiation Cell- and Tissue-Based Therapy Clinical uses of mesenchymal stem cells Bone Marrow Cells Mice SCID Biology Mesoderm Mice Mice Inbred NOD Ectoderm Animals Humans Cell Lineage Endothelium Progenitor cell Induced pluripotent stem cell Lung Stem cell transplantation for articular cartilage repair Bone Marrow Transplantation Multidisciplinary Stem Cells Mesenchymal stem cell Endoderm Cell Differentiation Tissue Therapy Cell biology Rats Intestines Haematopoiesis Blastocyst Liver Organ Specificity Radiation Chimera embryonic structures Immunology Stem cell Cell Division Stem Cell Transplantation |
| Popis: | We report here that cells co-purifying with mesenchymal stem cells--termed here multipotent adult progenitor cells or MAPCs--differentiate, at the single cell level, not only into mesenchymal cells, but also cells with visceral mesoderm, neuroectoderm and endoderm characteristics in vitro. When injected into an early blastocyst, single MAPCs contribute to most, if not all, somatic cell types. On transplantation into a non-irradiated host, MAPCs engraft and differentiate to the haematopoietic lineage, in addition to the epithelium of liver, lung and gut. Engraftment in the haematopoietic system as well as the gastrointestinal tract is increased when MAPCs are transplanted in a minimally irradiated host. As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases. ispartof: Nature vol:418 issue:6893 pages:41-9 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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