Toxoplasmosis and abortion: pro- and anti-inflammatory cytokines gene expression of the host immune cells
| Autor: | Mohamed S. Badr, Walid El-Sherbiny, Mohamed S. Salama, Inas Z. Abdel Aziz, Ghada M. Nasr, Samar S. Attia, Mona El-Sherbini, Amany A Abd El-Aal |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
TGF-β lcsh:QH426-470 q-PCR 03 medical and health sciences 0302 clinical medicine Immune system Downregulation and upregulation Gene expression medicine IFN-γ Genetics (clinical) Pregnancy lcsh:R5-920 business.industry medicine.disease Toxoplasmosis Interleukin 10 lcsh:Genetics 030104 developmental biology Real-time polymerase chain reaction 030220 oncology & carcinogenesis TNF-α Immunology Gestation business lcsh:Medicine (General) Toxoplasma IL10 |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 20, Iss 1, Pp 1-10 (2019) |
| ISSN: | 2090-2441 |
| DOI: | 10.1186/s43042-019-0006-5 |
| Popis: | Background Toxoplasmosis during pregnancy is known for inducing variable serious outcomes. In many previous studies, pregnancy was evaluated as a single event while in reality; it has different distinct immunological stages depending on gestational time and possible external factors as infectious agents. A state of immunological balance as well as a state of maternal-fetal tolerance should be established; otherwise, atypical unwelcomed outcomes might occur as a result of such infection Aim This work aimed to study the gene expression profile of some pro- and anti-inflammatory cytokines in Toxoplasma seropositive cases Results All studied cytokines were significantly upregulated in group I, with a remarkable bias towards IFN-γ, denoting a predominant inflammatory state in group I. In group II; tested cytokines were approximately in a balanced state with a little shift towards anti-inflammatory cytokines (IL-10 and TGF-β). A significant positive correlation was detected between pro-inflammatory together (p = 0.002, r = 0.96) and between anti-inflammatory cytokines together (p = 0.0008, r = 0.99) in group II, indicating the harmonized and synchronized expression of both pro- and anti-inflammatory cytokines. In group III, IL-10 was relatively higher with negative correlation with IFN-γ (p = 0.006, r = 0.93), indicating the possible role of IL10 in saving some of the pregnancies’ outcomes in group III. Conclusion The present study suggests a potential role of these cytokines in the upcoming prognostic or/and therapeutic concerns of toxoplasmosis among pregnant women. |
| Databáze: | OpenAIRE |
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