Investigations of octylglyceryl dextran- graft -poly(lactic acid) nanoparticles for peptide delivery to the brain
| Autor: | Boussahel, Asme, Ibegbu, Daniel, Lamtahri, Rhita, Maucotel, Julie, Chuquet, Julien, Lefranc, Benjamin, Leprince, Jérôme, Roldo, Marta, Mével, Jean-Claude Le, Gorecki, Darek, Barbu, Eugen, Chuquet, Julie |
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| Přispěvatelé: | Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), International Associated laboratory Samuel de Champlain, Institut National de la Recherche Scientifique [Québec] (INRS)-Université de Rouen Normandie (UNIROUEN), Neuroendocrinologie cellulaire et moléculaire, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Medicine (miscellaneous) Peptide 02 engineering and technology [CHIM.THER]Chemical Sciences/Medicinal Chemistry MESH: Blood-Brain Barrier Mice chemistry.chemical_compound Drug Delivery Systems [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] General Materials Science MESH: Animals MESH: Dextrans Cytotoxicity chemistry.chemical_classification MESH: Peptides Dextrans 021001 nanoscience & nanotechnology MESH: Polyesters Lactic acid Dextran Biochemistry Blood-Brain Barrier dextran Drug delivery 0210 nano-technology Materials science Polyesters brain education MESH: Drug Delivery Systems Biomedical Engineering Neuropeptide Bioengineering Development Cell Line 03 medical and health sciences MESH: Brain In vivo Animals Humans MESH: Particle Size Particle Size MESH: Mice MESH: Humans neuropeptides Biomedical Sciences Angiotensin II MESH: Cell Line 030104 developmental biology chemistry drug delivery [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology nanoparticles Peptides MESH: Nanoparticles |
| Zdroj: | Nanomedicine Nanomedicine, Future Medicine, 2017, 12 (8), pp.879-892. ⟨10.2217/nnm-2016-0406⟩ Boussahel, A, Ibegbu, D M, Lamtahri, R, Maucotel, J, Chuquet, J, Lefranc, B, Leprince, J, Roldo, M, Le Mével, J-C, Gorecki, D & Barbu, E 2017, ' Investigations of octylglyceryl dextran-graft-poly(lactic acid) nanoparticles for peptide delivery to the brain ', Nanomedicine, vol. 12, no. 8, pp. 879-892 . https://doi.org/10.2217/nnm-2016-0406 University of Bristol-PURE |
| ISSN: | 1743-5889 1748-6963 |
| DOI: | 10.2217/nnm-2016-0406⟩ |
| Popis: | Aim - Develop modified dextran nanoparticles showing potential to assist with drug permeation across the blood–brain barrier for the delivery of neuropeptides.Methods - Nanoparticles loaded by emulsification with model macromolecular actives were characterized in terms of stability, cytotoxicity and drug-release behavior. Peptide-loaded nanoformulations were tested in an in vivo trout model and in food-deprived mice. Results - Nanoformulations loaded with model peptides showed good stability and appeared nontoxic in low concentration against human brain endothelial cells. They were found to preserve the bioactivity of loaded peptides (angiotensin II) as demonstrated in vivo using a trout model, and to induce a transient reduction of food consumption in mice when loaded with an anorexigenic octaneuropeptide. Conclusion - Octylglyceryl dextran-graft-poly(lactic acid) nanoparticles formulated by emulsification demonstrate potential for peptide delivery. |
| Databáze: | OpenAIRE |
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