Direct and indirect stimulations of cyclic AMP formation in human brain
| Autor: | Paul Millns, J.L. Firth, David A. Kendall |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Adenosine Histamine H1 receptor In Vitro Techniques Biology Norepinephrine chemistry.chemical_compound Species Specificity Internal medicine Isoprenaline Cyclic AMP medicine Humans Cerebral Cortex Pyrilamine Pharmacology Forskolin Adenine Isoproterenol Glutamate receptor Prazosin Human brain medicine.anatomical_structure Endocrinology chemistry Cerebral cortex Female Histamine Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 105:899-902 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1992.tb09075.x |
| Popis: | 1. Adenosine 3':5'-cyclic monophosphate (cyclic AMP) formation, by use of an [3H]-adenine prelabelling assay, was measured in fragments of human cerebral cortex, taken in the course of various neurosurgical procedures. 2. Large accumulations of [3H]-cyclic AMP due to isoprenaline, noradrenaline and adenosine and small effects due to forskolin were observed. Histamine, 5-hydroxytryptamine (5-HT) and the excitatory amino acids glutamate and quisqualate were ineffective. 3. The response to noradrenaline consisted of two components; a direct beta-adrenoceptor response and an enhancement mediated by an alpha-adrenoceptor which appears to be similar to that in rat cerebral cortex. 4. The response to isoprenaline was also potentiated by histamine H1 receptor stimulation but the direct effect of 2-chloroadenosine was not altered by histamine, 5-HT or quisqualate. 5. It is concluded that some, but not all, of the indirect modulations of cyclic AMP formation previously observed in experimental animal brain exist in human cerebral cortex. |
| Databáze: | OpenAIRE |
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