Treadmill Exercise Ameliorates Adult Hippocampal Neurogenesis Possibly by Adjusting the APP Proteolytic Pathway in APP/PS1 Transgenic Mice
| Autor: | Bo Xu, Haizhen Yu, Jie Xia, Chenfei Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Genetically modified mouse
QH301-705.5 hippocampal microenvironment Transgene Neurogenesis APP proteolytic pathway Mice Transgenic Hippocampal formation Hippocampus Catalysis Article Inorganic Chemistry Amyloid beta-Protein Precursor Mice treadmill exercise Neurotrophic factors Alzheimer Disease Physical Conditioning Animal mental disorders Amyloid precursor protein Medicine Animals Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy biology Cell growth business.industry Organic Chemistry General Medicine hippocampal neurogenesis Computer Science Applications Disease Models Animal Chemistry Proteolysis biology.protein business Amyloid precursor protein secretase Neuroscience Alzheimer’s disease |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 17 International Journal of Molecular Sciences, Vol 22, Iss 9570, p 9570 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22179570 |
| Popis: | Alzheimer’s disease (AD) is a neurodegenerative disorder known to cause cognitive impairment among the elderly worldwide. Although physical exercise-induced adult hippocampal neurogenesis (AHN) improves cognition, understanding its underlying molecular mechanisms requires further investigation using AD mouse models. In this present work, we subjected amyloid precursor protein (APP)/PS1 mice to a 12-week aerobic treadmill exercise to investigate AHN and its potential mechanisms. We divided 3-month-old littermates wild-type and APP/PS1 transgenic male mice into four groups, and the exercise groups performed 12-week treadmill exercise. Next, we evaluated the influence of treadmill exercise on learning and memory capacity, AHN, and APP proteolytic pathway-related factors. As per our results, the treadmill exercise was able to improve the hippocampal microenvironment in APP/PS1 mice probably by regulating various neurotrophic factors and secretases resulting in APP cleavage through a non-amyloidogenic pathway, which seems to further promote new cell proliferation, survival, and differentiation, enhancing hippocampal neurogenesis. All of these effects ameliorate learning and memory capacity. This study provides a theoretical and experimental basis for understanding AHN in an AD mouse model, which is beneficial for preventing and treating AD. |
| Databáze: | OpenAIRE |
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